• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一名65岁男性的溶血性尿毒症综合征与一种非常罕见的携带stx2e和eae的O51:H49型产志贺毒素大肠杆菌有关。

Hemolytic uremic syndrome in a 65-Year-old male linked to a very unusual type of stx2e- and eae-harboring O51:H49 shiga toxin-producing Escherichia coli.

作者信息

Fasel Dominique, Mellmann Alexander, Cernela Nicole, Hächler Herbert, Fruth Angelika, Khanna Nina, Egli Adrian, Beckmann Christiane, Hirsch Hans H, Goldenberger Daniel, Stephan Roger

机构信息

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.

出版信息

J Clin Microbiol. 2014 Apr;52(4):1301-3. doi: 10.1128/JCM.03459-13. Epub 2014 Feb 5.

DOI:10.1128/JCM.03459-13
PMID:24501025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3993467/
Abstract

We report on a 65-year-old male patient with a Shiga toxin-producing Escherichia coli O51:H49 gastrointestinal infection and sepsis associated with hemolytic uremic syndrome (HUS) with a fatal outcome. The strains isolated harbored stx2e and eae, a very unusual and new virulence profile for an HUS-associated enterohemorrhagic E. coli.

摘要

我们报告了一名65岁男性患者，其感染了产志贺毒素的大肠杆菌O51:H49，引发胃肠道感染和败血症，并伴有溶血性尿毒症综合征（HUS），最终死亡。分离出的菌株携带stx2e和eae，这对于与HUS相关的肠出血性大肠杆菌来说是一种非常罕见的新毒力谱。

相似文献

1
Hemolytic uremic syndrome in a 65-Year-old male linked to a very unusual type of stx2e- and eae-harboring O51:H49 shiga toxin-producing Escherichia coli.一名65岁男性的溶血性尿毒症综合征与一种非常罕见的携带stx2e和eae的O51:H49型产志贺毒素大肠杆菌有关。
J Clin Microbiol. 2014 Apr;52(4):1301-3. doi: 10.1128/JCM.03459-13. Epub 2014 Feb 5.
2
Serotypes and virulence profiles of Shiga toxin-producing Escherichia coli strains isolated during 2017 from human infections in Switzerland.2017 年瑞士人感染病例中分离出的产志贺毒素大肠杆菌菌株的血清型和毒力特征。
Int J Med Microbiol. 2018 Oct;308(7):933-939. doi: 10.1016/j.ijmm.2018.06.011. Epub 2018 Jun 30.
3
Strong association between shiga toxin-producing Escherichia coli O157 and virulence genes stx2 and eae as possible explanation for predominance of serogroup O157 in patients with haemolytic uraemic syndrome.产志贺毒素大肠杆菌O157与毒力基因stx2和eae之间的强关联可能是溶血性尿毒综合征患者中O157血清群占优势的原因。
Eur J Clin Microbiol Infect Dis. 2003 Dec;22(12):726-30. doi: 10.1007/s10096-003-1025-0. Epub 2003 Nov 12.
4
Antibody response to lipopolysaccharides and recombinant proteins of Shiga toxin (STX)-producing Escherichia coli (STEC) in children with haemolytic uraemic syndrome in Poland.波兰溶血尿毒综合征患儿对产志贺毒素大肠杆菌（STEC）脂多糖和重组蛋白的抗体反应。
Lett Appl Microbiol. 2020 Jun;70(6):440-446. doi: 10.1111/lam.13295. Epub 2020 Apr 28.
5
Hemolytic uremic syndrome associated with Escherichia coli O8:H19 and Shiga toxin 2f gene.与大肠杆菌O8:H19及志贺毒素2f基因相关的溶血尿毒综合征
Emerg Infect Dis. 2015 Jan;21(1):168-9. doi: 10.3201/eid2101.140515.
6
Characterization of a novel plasmid encoding F4-like fimbriae present in a Shiga-toxin producing enterotoxigenic Escherichia coli isolated during the investigation on a case of hemolytic-uremic syndrome.鉴定一株产志贺毒素肠毒性大肠杆菌中新的 F4 样菌毛的特性，该菌是在对溶血尿毒综合征病例调查中分离得到的。
Int J Med Microbiol. 2018 Oct;308(7):947-955. doi: 10.1016/j.ijmm.2018.07.002. Epub 2018 Jul 11.
7
Escherichia coli harboring Shiga toxin 2 gene variants: frequency and association with clinical symptoms.携带志贺毒素2基因变体的大肠杆菌：频率及其与临床症状的关联
J Infect Dis. 2002 Jan 1;185(1):74-84. doi: 10.1086/338115. Epub 2001 Dec 14.
8
Be aware of Shiga-toxin 2f-producing Escherichia coli: case report and false-negative results with certain rapid molecular panels.注意产志贺毒素 2f 大肠杆菌：病例报告和某些快速分子检测试剂盒的假阴性结果。
Diagn Microbiol Infect Dis. 2020 Dec;98(4):115177. doi: 10.1016/j.diagmicrobio.2020.115177. Epub 2020 Aug 14.
9
Molecular Characterization of the Enterohemolysin Gene () in Clinical Shiga Toxin-Producing Isolates.临床产志贺毒素大肠埃希菌中肠出血性大肠埃希菌溶血素基因（）的分子特征。
Toxins (Basel). 2021 Jan 19;13(1):71. doi: 10.3390/toxins13010071.
10
Virulence factors of Shiga toxin-producing Escherichia coli and the risk of developing haemolytic uraemic syndrome in Norway, 1992-2013.产志贺毒素大肠杆菌的毒力因子与 1992-2013 年挪威溶血性尿毒综合征的发病风险。
Eur J Clin Microbiol Infect Dis. 2017 Sep;36(9):1613-1620. doi: 10.1007/s10096-017-2974-z. Epub 2017 Apr 8.

引用本文的文献

1
Rapid and Sensitive Detection of Shiga Toxin-Producing (STEC) from Food Matrices Using the CANARY Biosensor Assay.使用 CANARY 生物传感器检测食品基质中的产志贺毒素（STEC）：快速且灵敏。
Toxins (Basel). 2024 Jul 22;16(7):325. doi: 10.3390/toxins16070325.
2
A Comprehensive Review on Shiga Toxin Subtypes and Their Niche-Related Distribution Characteristics in Shiga-Toxin-Producing and Other Bacterial Hosts.关于志贺毒素亚型及其在产志贺毒素细菌和其他细菌宿主中与生态位相关的分布特征的综合综述
Microorganisms. 2024 Mar 28;12(4):687. doi: 10.3390/microorganisms12040687.
3
Development of a Rapid and Sensitive CANARY Biosensor Assay for the Detection of Shiga Toxin 2 from .开发一种快速灵敏的 CANARY 生物传感器检测方法，用于检测. 中的志贺毒素 2。
Toxins (Basel). 2024 Mar 14;16(3):148. doi: 10.3390/toxins16030148.
4
Pathogenic Factors and Recent Study on the Rapid Detection of Shiga Toxin-Producing Escherichia coli (STEC).产志贺毒素大肠杆菌（STEC）的致病因素及快速检测的最新研究
Mol Biotechnol. 2025 Jan;67(1):16-26. doi: 10.1007/s12033-023-00985-8. Epub 2023 Dec 28.
5
Characterization of Atypical Shiga Toxin Gene Sequences and Description of Stx2j, a New Subtype.非典型志贺毒素基因序列的特征描述及 Stx2j 新亚型的发现。
J Clin Microbiol. 2022 Mar 16;60(3):e0222921. doi: 10.1128/jcm.02229-21.
6
Genomic Characteristics of Stx2e-Producing Strains Derived from Humans, Animals, and Meats.源自人类、动物和肉类的产志贺毒素2e菌株的基因组特征
Pathogens. 2021 Nov 28;10(12):1551. doi: 10.3390/pathogens10121551.
7
Characterization of Clinical Strains Producing a Novel Shiga Toxin 2 Subtype in Sweden and Denmark.瑞典和丹麦产新型志贺毒素2亚型临床菌株的特征分析
Microorganisms. 2021 Nov 17;9(11):2374. doi: 10.3390/microorganisms9112374.
8
Locus of Heat Resistance (LHR) in Meat-Borne Escherichia coli: Screening and Genetic Characterization.肉类携带的大肠杆菌中的耐热位点（LHR）：筛选与遗传特征分析
Appl Environ Microbiol. 2021 Mar 11;87(7). doi: 10.1128/AEM.02343-20.
9
Validation of a Cell-Based Assay for Detection of Active Shiga Toxins Produced by in Water.用于检测水中产志贺毒素大肠杆菌所产生活性志贺毒素的细胞检测法的验证
Int J Environ Res Public Health. 2020 Oct 28;17(21):7901. doi: 10.3390/ijerph17217901.
10
Seasonal Prevalence of Shiga Toxin-Producing Escherichia coli on Pork Carcasses for Three Steps of the Harvest Process at Two Commercial Processing Plants in the United States.美国两家商业加工厂三个收获步骤的猪肉胴体中产志贺毒素大肠杆菌的季节性流行率。
Appl Environ Microbiol. 2020 Dec 17;87(1). doi: 10.1128/AEM.01711-20.

本文引用的文献

1
Therapy: Azithromycin and decolonization after HUS.治疗：溶血尿毒综合征后的阿奇霉素与去定植
Nat Rev Nephrol. 2012 May 1;8(6):317-8. doi: 10.1038/nrneph.2012.87.
2
Seropathotypes, Phylogroups, Stx subtypes, and intimin types of wildlife-carried, shiga toxin-producing escherichia coli strains with the same characteristics as human-pathogenic isolates.具有与人类致病性分离株相同特征的野生动物携带产志贺毒素大肠杆菌的血清型、 phylogroups、stx 亚型和 intimin 型。
Appl Environ Microbiol. 2012 Apr;78(8):2578-85. doi: 10.1128/AEM.07520-11. Epub 2012 Feb 3.
3
Specificity of PCR and serological assays in the detection of Escherichia coli Shiga toxin subtypes.PCR 和血清学检测在检测产志贺毒素大肠杆菌亚型中的特异性。
Appl Environ Microbiol. 2011 Sep;77(18):6699-702. doi: 10.1128/AEM.00370-11. Epub 2011 Jul 29.
4
Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study.2011 年德国一起溶血性尿毒综合征暴发相关大肠杆菌菌株的特征：一项微生物学研究。
Lancet Infect Dis. 2011 Sep;11(9):671-6. doi: 10.1016/S1473-3099(11)70165-7. Epub 2011 Jun 22.
5
Phenotypic and genotypic traits of Shiga toxin-negative E. coli O157:H7/H(-) bovine and porcine strains.志贺毒素阴性大肠杆菌O157:H7/H(-)牛和猪菌株的表型和基因型特征。
Foodborne Pathog Dis. 2009 Mar;6(2):235-43. doi: 10.1089/fpd.2008.0205.
6
Characterization of attaching and effacing Escherichia coli (AEEC) isolated from pigs and sheep.从猪和羊中分离出的紧密黏附性大肠杆菌（AEEC）的特性分析。
BMC Microbiol. 2008 Sep 11;8:144. doi: 10.1186/1471-2180-8-144.
7
Analysis of collection of hemolytic uremic syndrome-associated enterohemorrhagic Escherichia coli.溶血尿毒综合征相关肠出血性大肠杆菌的菌株分析
Emerg Infect Dis. 2008 Aug;14(8):1287-90. doi: 10.3201/eid1408.071082.
8
Serotypes and virutypes of enteropathogenic and enterohaemorrhagic Escherichia coli strains from stool samples of children with diarrhoea in Germany.德国腹泻儿童粪便样本中肠致病性和肠出血性大肠杆菌菌株的血清型和病毒型
J Appl Microbiol. 2008 Feb;104(2):403-10. doi: 10.1111/j.1365-2672.2007.03545.x. Epub 2007 Sep 21.
9
Subtyping method for Escherichia coli shiga toxin (verocytotoxin) 2 variants and correlations to clinical manifestations.大肠埃希菌志贺毒素（维罗毒素）2变体的分型方法及其与临床表现的相关性。
J Clin Microbiol. 2007 Jun;45(6):2020-4. doi: 10.1128/JCM.02591-06. Epub 2007 Apr 19.
10
Atypical enteropathogenic Escherichia coli infection and prolonged diarrhea in children.儿童非典型肠致病性大肠杆菌感染与迁延性腹泻
Emerg Infect Dis. 2006 Apr;12(4):597-603. doi: 10.3201/eid1204.051112.