Shiohara T, Moriya N, Tanaka Y, Arai Y, Hayakawa J, Chiba M, Nagashima M
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
J Am Acad Dermatol. 1988 Jan;18(1 Pt 1):67-74. doi: 10.1016/s0190-9622(88)70011-0.
Skin biopsy specimens from 24 patients with different lichenoid skin diseases that had been proved histologically were studied immunohistologically. Marked differences were noted in the number of OKT6+/S100+ Langerhans cells within the epidermis and dermis in the lesional skin between lichen planus (and its related disease) and lupus erythematosus; in the former these cells were increased in number; in the latter they were decreased in number compared with those in uninvolved perilesional skin. Human lymphocyte antigen (HLA)-DR expression on keratinocytes was observed not only in lichenoid skin diseases but also in control cases without epidermal involvement. In the two cases of systemic lupus erythematosus, the uninvolved perilesional skin also show weak and focal HLA-DR reactivity in the basal layer. HLA-DR+ keratinocytes could play an important role at least in the perpetuation of epidermal cell damage mediated by T cells.
对24例经组织学证实患有不同苔藓样皮肤病的患者的皮肤活检标本进行了免疫组织学研究。在扁平苔藓（及其相关疾病）和红斑狼疮的皮损中，表皮和真皮内OKT6+/S100+朗格汉斯细胞的数量存在显著差异；在前者中，这些细胞数量增加；在后者中，与未受累的皮损周围皮肤相比，它们的数量减少。不仅在苔藓样皮肤病中，而且在无表皮受累的对照病例中，均观察到角质形成细胞上的人类淋巴细胞抗原（HLA）-DR表达。在两例系统性红斑狼疮病例中，未受累的皮损周围皮肤在基底层也显示出微弱的局灶性HLA-DR反应性。HLA-DR+角质形成细胞至少在T细胞介导的表皮细胞损伤的持续存在中可能起重要作用。
