来自单纯疱疹病毒糖蛋白D的合成肽片段上重叠的T细胞抗原位点、引发的简并性MHC限制以及抗原与Ia相互作用的功能证据。
Overlapping T cell antigenic sites on a synthetic peptide fragment from herpes simplex virus glycoprotein D, the degenerate MHC restriction elicited, and functional evidence for antigen-Ia interaction.
作者信息
Heber-Katz E, Valentine S, Dietzschold B, Burns-Purzycki C
机构信息
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
出版信息
J Exp Med. 1988 Feb 1;167(2):275-87. doi: 10.1084/jem.167.2.275.
Abstract
Analysis of the B10.A T cell response to synthetic peptides representing the NH2-terminal 23 amino acids from the HSV glycoprotein D sequence revealed two antigenic determinants for T cells: one localized between residues 1-16 and the other between residues 8-23. The 1-16 site, which is helical, was recognized in the context of the Ia molecule, whereas the 8-23 site, which is nonhelical, was recognized in the context of the I-E molecule. The I-E-restricted response was found to be highly MHC degenerate in that T cell hybridomas specific for the 8-23 peptide responded to antigen on APCs derived from B10.A, B10.A(5R), and B10.A(9R) mice and showed differences in antigenic fine specificity with APCs of different haplotypes. These data support the idea of antigen-Ia interaction.
摘要
对B10.A T细胞针对代表单纯疱疹病毒糖蛋白D序列氨基端23个氨基酸的合成肽的反应进行分析，发现了T细胞的两个抗原决定簇：一个位于第1 - 16位残基之间，另一个位于第8 - 23位残基之间。1 - 16位点呈螺旋状，在Ia分子的背景下被识别，而8 - 23位点是非螺旋状的，在I - E分子的背景下被识别。发现I - E限制的反应具有高度的MHC简并性，因为针对8 - 23肽的T细胞杂交瘤对来自B10.A、B10.A(5R)和B10.A(9R)小鼠的抗原呈递细胞（APC）上的抗原产生反应，并且与不同单倍型的APC在抗原精细特异性上存在差异。这些数据支持抗原与Ia相互作用的观点。
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Overlapping T cell antigenic sites on a synthetic peptide fragment from herpes simplex virus glycoprotein D, the degenerate MHC restriction elicited, and functional evidence for antigen-Ia interaction.来自单纯疱疹病毒糖蛋白D的合成肽片段上重叠的T细胞抗原位点、引发的简并性MHC限制以及抗原与Ia相互作用的功能证据。
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