Mengle-Gaw L, McDevitt H O
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7621-5. doi: 10.1073/pnas.80.24.7621.
The Ia antigens, encoded within the I region of the major histocompatibility complex, are a group of cell surface glycoproteins that are involved in the control of immune responsiveness. We isolated and determined the sequence of a 1,045-base-pair cDNA clone for one of the murine immune response genes, Ek beta. Comparison of the predicted amino acid sequence of the product of Ek beta with that of Ed beta shows that most of the amino acid differences are clustered in short stretches of peptide sequence in the first external protein domain. This clustering of allelic variation suggests that observed haplotype-specific immune responsiveness to certain antigens may be controlled, at least in part, by differences in configuration defined by these regions of allelic variability in the NH2-terminal domain of the E beta chain.
Ia抗原由主要组织相容性复合体的I区编码，是一组参与免疫反应控制的细胞表面糖蛋白。我们分离并测定了小鼠免疫反应基因之一Ek beta的一个1045个碱基对的cDNA克隆的序列。将Ek beta产物的预测氨基酸序列与Ed beta的序列进行比较，结果表明，大多数氨基酸差异集中在第一个外部蛋白质结构域的短肽序列片段中。等位基因变异的这种聚集表明，观察到的对某些抗原的单倍型特异性免疫反应可能至少部分地由Eβ链NH2末端结构域中这些等位基因变异区域所定义的构象差异所控制。
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