单纯疱疹病毒糖蛋白D型特异性和型共同抗原位点的精细结构分析
Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D.
作者信息
Dietzschold B, Eisenberg R J, Ponce de Leon M, Golub E, Hudecz F, Varrichio A, Cohen G H
出版信息
J Virol. 1984 Nov;52(2):431-5. doi: 10.1128/JVI.52.2.431-435.1984.
Abstract
The fine structure of the antigenic determinants of herpes simplex virus type 1 and 2 glycoprotein D (gD) was analyzed to determine whether structural differences underlie the differential immunogenicity of these glycoproteins. A region common to herpes simplex virus type 1 and 2 gD (amino acid residues 11 to 19) and two sites specific for herpes simplex virus type 2 gD (one determined by proline at position 7, the other determined by asparagine at position 21) were localized within the N-terminal 23 amino acids of gD by synthesis of peptides and comparison of their cross-reactivity with antisera raised to herpes simplex virus type 1 and 2 gD. The secondary structure of these peptides, as predicted by computer analysis, is discussed in relation to their immunogenicity.
摘要
分析了单纯疱疹病毒1型和2型糖蛋白D（gD）抗原决定簇的精细结构，以确定这些糖蛋白免疫原性差异的结构基础。通过肽合成以及比较它们与针对单纯疱疹病毒1型和2型gD产生的抗血清的交叉反应性，在gD的N端23个氨基酸内定位了单纯疱疹病毒1型和2型gD的共同区域（氨基酸残基11至19）以及单纯疱疹病毒2型gD特有的两个位点（一个由第7位的脯氨酸决定，另一个由第21位的天冬酰胺决定）。根据计算机分析预测的这些肽的二级结构，结合它们的免疫原性进行了讨论。
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