Dalmoro Annalisa, Barba Anna Angela, d'Amore Matteo
Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy.
ScientificWorldJournal. 2013 Dec 31;2013:482910. doi: 10.1155/2013/482910. eCollection 2013.
Microencapsulation techniques are widely applied in the field of pharmaceutical production to control drugs release in time and in physiological environments. Ultrasonic-assisted atomization is a new technique to produce microencapsulated systems by a mechanical approach. Interest in this technique is due to the advantages evidenceable (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) when comparing it to more conventional techniques. In this paper, the groundwork of atomization is introduced, the role of relevant parameters in ultrasonic atomization mechanism is discussed, and correlations to predict droplets size starting from process parameters and material properties are presented and tested.
微囊化技术在药物生产领域被广泛应用，以控制药物在生理环境中的定时释放。超声辅助雾化是一种通过机械方法生产微囊化系统的新技术。与更传统的技术相比，人们对该技术感兴趣是因为它具有明显的优势（材料中的机械应力水平低、能量需求降低、设备尺寸减小）。本文介绍了雾化的基础，讨论了相关参数在超声雾化机制中的作用，并给出并测试了从工艺参数和材料特性预测液滴尺寸的相关性。
