Issazadeh-Navikas Shohreh
Neuroinflammation Unit; Biotech Research & Innovation Centre (BRIC); University of Copenhagen; Copenhagen, Denmark.
Oncoimmunology. 2013 Dec 1;2(12):e27091. doi: 10.4161/onci.27091. Epub 2013 Nov 11.
Anticancer immunotherapies are highly desired. Conversely, unwanted inflammatory or immune responses contribute to oncogenesis, tumor progression, and cancer-related death. For non-immunogenic therapies to inhibit tumor growth, they must promote, not prevent, the activation of anticancer immune responses. Here, the central immunoregulatory role of brain-specific stromal cells and neurons as well as their ability to maintain an immunological balance and prevent the development of glioblastoma is discussed.
抗癌免疫疗法备受期待。相反，不必要的炎症或免疫反应会促进肿瘤发生、肿瘤进展及癌症相关死亡。对于非免疫原性疗法而言，若要抑制肿瘤生长，就必须促进而非阻止抗癌免疫反应的激活。在此，将讨论脑特异性基质细胞和神经元的核心免疫调节作用，以及它们维持免疫平衡和预防胶质母细胞瘤发生的能力。
