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基于滚环扩增的 DNA 机器用于 miRNA 筛选，该机器将催化发夹组装与 DNA 酶形成偶联。

A rolling circle amplification-based DNA machine for miRNA screening coupling catalytic hairpin assembly with DNAzyme formation.

机构信息

Key Laboratory of Analysis and Detection of Food Safety (Ministry of Education & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou 350108, P.R. China.

出版信息

Chem Commun (Camb). 2014 Mar 18;50(22):2935-8. doi: 10.1039/c3cc49873e. Epub 2014 Feb 6.

DOI:10.1039/c3cc49873e
PMID:24501741
Abstract

A novel DNA nanomachine based on the linear rolling circle amplification strategy was designed for sensitive screening of microRNA (miRNA) at an ultralow concentration coupling catalytic hairpin assembly (CHA) with DNAzyme formation.

摘要

设计了一种基于线性滚环扩增策略的新型 DNA 纳米机器，用于在超低频浓度下通过催化发夹组装 (CHA) 与 DNA 酶形成来灵敏筛选 microRNA (miRNA)。

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