Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China.
Chem Commun (Camb). 2019 Jun 11;55(46):6519-6522. doi: 10.1039/c9cc02637a. Epub 2019 May 17.
A facile cross-catalytic circuit is engineered for intracellular microRNA (miRNA) imaging by facilely integrating a catalytic hairpin assembly (CHA) amplifier and DNAzyme biocatalyst through an ingenious feedback loop. These two indispensable catalytic reactions play vital roles in executing high-performance signal amplification, as demonstrated experimentally and theoretically.
通过巧妙的反馈环，轻松地将催化发夹组装（CHA）放大器和 DNA zyme 生物催化剂集成在一起，为细胞内 microRNA（miRNA）成像工程设计了一种简便的交叉催化电路。这两个不可或缺的催化反应在执行高性能信号放大方面发挥了重要作用，这在实验和理论上都得到了证明。
