局部辣椒素预处理可抑制生长抑素和血管活性肠肽在人体皮肤中引起的轴突反射性血管舒张。
Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin.
作者信息
Anand P, Bloom S R, McGregor G P
出版信息
Br J Pharmacol. 1983 Apr;78(4):665-9. doi: 10.1111/j.1476-5381.1983.tb09418.x.
Abstract
1 Wheal and flare reactions are described following intradermal injections of somatostatin, vasoactive intestinal polypeptide, substance P and histamine in normal human forearm skin. Bombesin failed to produce a significant wheal and flare.2 Pretreatment of skin with capsaicin in all cases dramatically inhibited the flare but not the wheal. This result is in accord with the hypothesis that capsaicin blocks the effector side of the axon reflex, perhaps by depleting nerve terminals of vasodilatory peptide(s).
摘要
1 在正常人体前臂皮肤进行皮内注射生长抑素、血管活性肠肽、P物质和组胺后，出现了风团及潮红反应。蛙皮素未能引起显著的风团及潮红。2 在所有病例中，用辣椒素预处理皮肤可显著抑制潮红，但不能抑制风团。该结果与如下假说相符：辣椒素可能通过耗尽血管舒张肽的神经末梢来阻断轴突反射的效应器侧。
相似文献
1
Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin.局部辣椒素预处理可抑制生长抑素和血管活性肠肽在人体皮肤中引起的轴突反射性血管舒张。
Br J Pharmacol. 1983 Apr;78(4):665-9. doi: 10.1111/j.1476-5381.1983.tb09418.x.
2
Inhibition of axon reflex vasodilatation by topically applied capsaicin.局部应用辣椒素对轴突反射性血管舒张的抑制作用。
J Invest Dermatol. 1981 May;76(5):394-5. doi: 10.1111/1523-1747.ep12520912.
3
Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin.辣椒素局部治疗后人体皮肤对轻度损伤的血管和感觉反应。
Br J Pharmacol. 1981 Jul;73(3):755-8. doi: 10.1111/j.1476-5381.1981.tb16812.x.
4
Investigation of mechanisms of the flare and wheal reactions in human skin by band method.用皮内注射法研究人体皮肤风团及潮红反应的机制。
Brain Res. 1988 May 24;449(1-2):328-31. doi: 10.1016/0006-8993(88)91047-5.
5
Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex.组胺通过P物质从皮肤中释放出来，但在轴突反射中并非最终的血管扩张剂。
Br J Pharmacol. 1986 Aug;88(4):741-5. doi: 10.1111/j.1476-5381.1986.tb16246.x.
6
Structure-activity relationships for some substance P-related peptides that cause wheal and flare reactions in human skin.一些在人体皮肤中引起风团和潮红反应的P物质相关肽的构效关系。
J Physiol. 1983 Feb;335:449-65. doi: 10.1113/jphysiol.1983.sp014543.
7
Axon reflex vasodilatation in human skin measured by a laser Doppler technique.用激光多普勒技术测量人体皮肤中的轴突反射性血管舒张。
Jpn J Physiol. 1991;41(5):693-702. doi: 10.2170/jjphysiol.41.693.
8
Axon reflex flare evoked by nicotine in human skin.尼古丁诱发的人体皮肤轴突反射性潮红
Jpn J Physiol. 1992;42(5):721-30. doi: 10.2170/jjphysiol.42.721.
9
Effects of capsaicin on cutaneous vasodilator responses in humans.
Agents Actions. 1992 Sep;37(1-2):53-9. doi: 10.1007/BF01987890.
10
Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis.通过皮内微透析测量人体皮肤中的血浆外渗和神经肽释放。
Neurosci Lett. 1997 Jul 18;230(2):117-20. doi: 10.1016/s0304-3940(97)00494-1.
引用本文的文献
1
Differences in the autonomic regulation of temperature in the lower lip and tongue during activation of the lingual nerve.舌神经激活期间下唇和舌部温度自主调节的差异。
J Physiol Sci. 2025 Jul;75(2):100028. doi: 10.1016/j.jphyss.2025.100028. Epub 2025 Jun 4.
2
Architecture of the Cutaneous Autonomic Nervous System.皮肤自主神经系统的结构
Front Neurol. 2019 Sep 10;10:970. doi: 10.3389/fneur.2019.00970. eCollection 2019.
3
Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions.辣椒素：物理化学性质、皮肤反应及其在疼痛和炎症性疾病中的潜在应用
Exp Ther Med. 2019 Aug;18(2):916-925. doi: 10.3892/etm.2019.7513. Epub 2019 Apr 19.
4
Cutaneous nociception and neurogenic inflammation evoked by PACAP38 and VIP.由 PACAP38 和 VIP 引起的皮肤伤害感受和神经源性炎症。
J Headache Pain. 2010 Aug;11(4):309-16. doi: 10.1007/s10194-010-0214-3. Epub 2010 May 9.
5
Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury.感觉神经纤维中的P物质会促使大鼠后爪在热损伤后出现水肿。
Br J Pharmacol. 1984 May;82(1):217-22. doi: 10.1111/j.1476-5381.1984.tb16461.x.
6
Blockade of the flare response to intradermal 5-hydroxytryptamine in man by MDL 72.222, a selective antagonist at neuronal 5-hydroxytryptamine receptors.MDL 72.222（一种神经元5-羟色胺受体的选择性拮抗剂）对人皮内注射5-羟色胺的潮红反应的阻断作用。
Eur J Clin Pharmacol. 1986;30(2):209-12. doi: 10.1007/BF00614305.
7
Sensory neuropeptide effects in human skin.感觉神经肽对人体皮肤的影响。
Br J Pharmacol. 1987 Dec;92(4):781-8. doi: 10.1111/j.1476-5381.1987.tb11381.x.
8
Allergy or inflammation? From neuropeptide stimulation of human skin mast cells to studies on the mechanism of the late asthmatic response.过敏还是炎症？从神经肽对人皮肤肥大细胞的刺激到对迟发性哮喘反应机制的研究。
Agents Actions. 1989 Jan;26(1-2):22-30. doi: 10.1007/BF02126554.
9
NK-1 receptor mediation of neurogenic plasma extravasation in rat skin.大鼠皮肤中神经源性血浆外渗的NK-1受体介导作用。
Br J Pharmacol. 1989 Aug;97(4):1232-8. doi: 10.1111/j.1476-5381.1989.tb12583.x.
10
Mast cells, neuropeptides and inflammation.肥大细胞、神经肽与炎症
Agents Actions. 1989 Apr;27(1-2):8-16. doi: 10.1007/BF02222185.
本文引用的文献
1
The value of axon responses in determining the site of lesion in traction injuries of the brachial plexus.轴突反应在确定臂丛神经牵拉伤损伤部位中的价值。
Brain. 1954 Dec;77(4):588-609. doi: 10.1093/brain/77.4.588.
2
The nature and the distribution of afferent fibres provided with the axon reflex arrangement.具有轴突反射装置的传入纤维的性质和分布。
Acta Physiol Scand. 1953 Nov 17;29(4):359-70. doi: 10.1111/j.1748-1716.1953.tb01032.x.
3
Effects of capsaicin applied locally to adult peripheral nerve. I. Physiology of peripheral nerve and spinal cord.辣椒素局部应用于成人周围神经的作用。I. 周围神经和脊髓的生理学
Pain. 1981 Dec;11(3):363-77. doi: 10.1016/0304-3959(81)90636-9.
4
Bombesin-like peptides in rat spinal cord: biochemical characterization, localization and mechanism of release.大鼠脊髓中类蛙皮素肽：生化特性、定位及释放机制
Life Sci. 1981 Nov 30;29(22):2273-9. doi: 10.1016/0024-3205(81)90560-9.
5
Increase in tissue concentrations of histamine and 5-hydroxytryptamine following capsaicin treatment of newborn rats.辣椒素处理新生大鼠后组胺和5-羟色胺组织浓度的增加。
Life Sci. 1981 Sep 14;29(11):1099-105. doi: 10.1016/0024-3205(81)90197-1.
6
Direct evidence for an axonal site of action of capsaicin.辣椒素作用于轴突位点的直接证据。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Aug;313(1):91-4. doi: 10.1007/BF00505809.
7
Inflammatory peptide in spinal cord: evidence that the mediator of antidromic vasodilatation is not substance P.脊髓中的炎性肽：逆向性血管舒张介质并非P物质的证据。
Neurosci Lett. 1980 May 15;18(1):99-103. doi: 10.1016/0304-3940(80)90219-0.
8
Intrathecal substance P and somatostatin in rats: behaviors indicative of sensation.大鼠鞘内注射P物质和生长抑素：感觉相关行为
Peptides. 1982 Jan-Feb;3(1):49-54. doi: 10.1016/0196-9781(82)90141-3.
9
Effects of capsaicin applied locally to adult peripheral nerve. II. Anatomy and enzyme and peptide chemistry of peripheral nerve and spinal cord.
Pain. 1981 Dec;11(3):379-88. doi: 10.1016/0304-3959(81)90637-0.
10
Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin.辣椒素局部治疗后人体皮肤对轻度损伤的血管和感觉反应。
Br J Pharmacol. 1981 Jul;73(3):755-8. doi: 10.1111/j.1476-5381.1981.tb16812.x.
Zotero 插件