局部辣椒素预处理可抑制生长抑素和血管活性肠肽在人体皮肤中引起的轴突反射性血管舒张。
Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin.
作者信息
Anand P, Bloom S R, McGregor G P
出版信息
Br J Pharmacol. 1983 Apr;78(4):665-9. doi: 10.1111/j.1476-5381.1983.tb09418.x.
Abstract
1 Wheal and flare reactions are described following intradermal injections of somatostatin, vasoactive intestinal polypeptide, substance P and histamine in normal human forearm skin. Bombesin failed to produce a significant wheal and flare.2 Pretreatment of skin with capsaicin in all cases dramatically inhibited the flare but not the wheal. This result is in accord with the hypothesis that capsaicin blocks the effector side of the axon reflex, perhaps by depleting nerve terminals of vasodilatory peptide(s).
摘要
1 在正常人体前臂皮肤进行皮内注射生长抑素、血管活性肠肽、P物质和组胺后，出现了风团及潮红反应。蛙皮素未能引起显著的风团及潮红。2 在所有病例中，用辣椒素预处理皮肤可显著抑制潮红，但不能抑制风团。该结果与如下假说相符：辣椒素可能通过耗尽血管舒张肽的神经末梢来阻断轴突反射的效应器侧。
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