Jonas R A, Ziemer G, Schoen F J, Britton L, Castaneda A R
Department of Cardiac Surgery, Children's Hospital, Boston, MA 02115.
J Vasc Surg. 1988 Mar;7(3):414-9. doi: 10.1067/mva.1988.avs0070414.
There has been a resurgence of interest in the concept of presealing high-porosity knitted Dacron prostheses with an absorbable biologic material. Such a material should provide reliable porosity control, preferably reducing water porosity from 2000 ml/cm2/min to less than 50 ml/cm2/min. It should not interfere with the fibrous and vascular ingrowth that securely anchors the developing pseudointima. In previous studies, we have examined fibrin glue and two forms of aldehyde cross-linked insoluble collagen used as Dacron sealants. We concluded that delayed resorption of the sealant as seen with glutaraldehyde cross-linked insoluble collagen results in undesirable healing characteristics, particularly lack of adhesion between pseudointima and the luminal surface of a prosthesis. This study examines a new sealant. Soluble collagen (gelatin) is treated to reduce the number of free amino groups available for aldehyde cross-linking. It is then weakly cross-linked with an aldehyde mixture and applied to a knitted Dacron prosthesis. Water porosity studies have confirmed satisfactory porosity control. Both rat subcutaneous and canine circulatory implants for 6 months reveal relatively rapid and complete sealant resorption without undesirable modification of the normal healing process of knitted Dacron.
用可吸收生物材料对高孔隙率针织涤纶人工血管进行预封闭这一概念重新引起了人们的关注。这样一种材料应能提供可靠的孔隙率控制，最好将水孔隙率从2000毫升/平方厘米/分钟降低到50毫升/平方厘米/分钟以下。它不应干扰能牢固锚定正在形成的假内膜的纤维和血管向内生长。在先前的研究中，我们研究了用作涤纶封闭剂的纤维蛋白胶和两种醛交联不溶性胶原形式。我们得出结论，戊二醛交联不溶性胶原所表现出的封闭剂延迟吸收会导致不良的愈合特性，尤其是假内膜与人工血管腔表面之间缺乏黏附。本研究考察了一种新的封闭剂。对可溶性胶原（明胶）进行处理以减少可用于醛交联的游离氨基数量。然后将其与醛混合物进行弱交联，并应用于针织涤纶人工血管。水孔隙率研究证实了令人满意的孔隙率控制。大鼠皮下植入和犬类循环植入6个月的结果均显示，封闭剂吸收相对迅速且完全，对针织涤纶的正常愈合过程没有不良影响。
