Jonas R A, Schoen F J, Levy R J, Castaneda A R
Ann Thorac Surg. 1986 Jun;41(6):657-63. doi: 10.1016/s0003-4975(10)63083-4.
Woven Dacron used in extracardiac conduits tends to form a poorly adherent, obstructing layer of pseudointima. Knitted high-porosity conduits allow fibrous and vascular ingrowth and more secure anchoring of the pseudointima. However, at the time of insertion, the porosity rate must be sufficiently low to prevent excessive bleeding in the heparinized patient. Pretreatments with biological sealants are available to temporarily reduce the porosity of knitted Dacron at the time of implantation with subsequent resorption of the sealant. We compared in vitro water porosity rates of knitted Dacron pretreated with conventional techniques, fibrin glue, and collagen impregnation. Only the collagen-impregnated and fibrin glue-treated grafts decreased the porosity of knitted Dacron to an acceptable level. To assess the biocompatibility and resorption of biomaterials used in sealing conduits, pretreated Dacron was implanted subcutaneously in weaning rats. Foreign-body response of untreated Dacron was unchanged by conventional techniques. Fibrin glue also resulted in good capillary ingrowth as well as occasional punctate multifocal deposits of calcium phosphate. The collagen-impregnated grafts differed in the intensity of the inflammatory response and tissue adhesion, possibly related to the degree of collagen cross-linking. This may have important implications regarding structure of the pseudointima in vascular grafts sealed with these materials.
用于心外管道的编织涤纶往往会形成一层附着性差且会造成阻塞的假内膜层。针织高孔隙率管道允许纤维和血管向内生长，并使假内膜的锚定更牢固。然而，在植入时，孔隙率必须足够低，以防止肝素化患者过度出血。可以使用生物密封剂进行预处理，以在植入时暂时降低针织涤纶的孔隙率，随后密封剂会被吸收。我们比较了用传统技术、纤维蛋白胶和胶原浸渍预处理的针织涤纶的体外水孔隙率。只有经胶原浸渍和纤维蛋白胶处理的移植物将针织涤纶的孔隙率降低到了可接受的水平。为了评估用于密封管道的生物材料的生物相容性和吸收情况，将预处理的涤纶皮下植入断奶大鼠体内。传统技术并未改变未处理涤纶的异物反应。纤维蛋白胶还导致了良好的毛细血管向内生长以及偶尔出现的磷酸钙点状多灶性沉积。经胶原浸渍的移植物在炎症反应强度和组织粘连方面有所不同，这可能与胶原交联程度有关。这可能对用这些材料密封的血管移植物中假内膜的结构具有重要意义。
