Vos Ad, Kretzschmar Antje, Ortmann Steffen, Lojkic Ivana, Habla Christiane, Müller Thomas, Kaiser Christian, Hundt Boris, Schuster Peter
1 IDT Biologika GmbH, Am Pharmapark, 06861 Dessau-Rosslau, Germany.
J Wildl Dis. 2013 Oct;49(4):1033-6. doi: 10.7589/2013-02-035.
The small Indian mongoose (Herpestes auropunctatus), a rabies reservoir species on several Islands in the Caribbean, was successfully immunized against rabies for the first time by offering animals a vaccine bait specifically designed for this small carnivore. The bait contained on average 0.6 mL of the genetically modified replication-competent rabies virus construct SPBN GASGAS (10(8.5) focus-forming units/mL). Three of four mongooses offered a bait developed an immune response above 0.5 IU/mL, but the response was less pronounced than in two animals offered the vaccine by direct oral instillation.
小印度猫鼬（Herpestes auropunctatus）是加勒比地区几个岛屿上的狂犬病宿主物种，通过为其提供专门为这种小型食肉动物设计的疫苗诱饵，首次成功对其进行了狂犬病免疫。该诱饵平均含有0.6毫升基因改造的具有复制能力的狂犬病病毒构建体SPBN GASGAS（10(8.5) 蚀斑形成单位/毫升）。四只接受诱饵的猫鼬中有三只产生了高于0.5国际单位/毫升的免疫反应，但该反应不如通过直接口服给药方式接种疫苗的两只动物明显。
