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Integrin, the cell surface receptor for fibronectin and laminin, expresses the L2/HNK-1 and L3 carbohydrate structures shared by adhesion molecules.

作者信息

Pesheva P, Horwitz A F, Schachner M

机构信息

Department of Neurobiology, University of Heidelberg, F.R.G.

出版信息

Neurosci Lett. 1987 Dec 29;83(3):303-6. doi: 10.1016/0304-3940(87)90104-2.

DOI:10.1016/0304-3940(87)90104-2
PMID:2450314
Abstract

On the basis of recent evidence that the carbohydrate structures designated L2/HNK-1 and L3 are shared by several neural adhesion molecules including L1, N-CAM, the myelin-associated glycoprotein and J1, we have suggested that other members of the L2/HNK-1 and L3 families are adhesion molecules. Here we show by Western blot analysis that integrin, the cell surface receptor for the extracellular matrix constituents fibronectin and laminin in chicken, also expresses the L2/HNK-1 and L3 epitopes and thus is another family member proven to be involved in adhesion.

摘要

相似文献

1
Integrin, the cell surface receptor for fibronectin and laminin, expresses the L2/HNK-1 and L3 carbohydrate structures shared by adhesion molecules.
Neurosci Lett. 1987 Dec 29;83(3):303-6. doi: 10.1016/0304-3940(87)90104-2.
2
Monoclonal antibody detects carbohydrate microheterogeneity on the murine cell adhesion molecule L1.单克隆抗体可检测小鼠细胞黏附分子L1上的碳水化合物微异质性。
Neurosci Lett. 1987 Dec 29;83(3):327-32. doi: 10.1016/0304-3940(87)90109-1.
3
The peripheral myelin glycoprotein P0 expresses the L2/HNK-1 and L3 carbohydrate structures shared by neural adhesion molecules.外周髓磷脂糖蛋白P0表达神经黏附分子共有的L2/HNK-1和L3碳水化合物结构。
Neurosci Lett. 1987 Nov 10;82(1):77-82. doi: 10.1016/0304-3940(87)90174-1.
4
L1/HNK-1 carbohydrate- and beta 1 integrin-dependent neural cell adhesion to laminin-1.L1/HNK-1碳水化合物和β1整合素依赖性神经细胞与层粘连蛋白-1的黏附。
J Neurochem. 1997 Feb;68(2):544-53. doi: 10.1046/j.1471-4159.1997.68020544.x.
5
Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvomorulin, laminin, fibronectin, and a heparan sulfate proteoglycan) in embryonic, adult, and denervated adult skeletal muscle.几种黏附大分子（神经细胞黏附分子、L1、J1、NILE、桥粒芯糖蛋白、层粘连蛋白、纤连蛋白和一种硫酸乙酰肝素蛋白聚糖）在胚胎、成年和去神经支配的成年骨骼肌中的表达。
J Cell Biol. 1986 Feb;102(2):420-31. doi: 10.1083/jcb.102.2.420.
6
The J1 glycoprotein--a novel nervous system cell adhesion molecule of the L2/HNK-1 family.J1糖蛋白——L2/HNK-1家族的一种新型神经系统细胞粘附分子。
Nature. 1985;316(6024):146-8. doi: 10.1038/316146a0.
7
The human laminin receptor is a member of the integrin family of cell adhesion receptors.人层粘连蛋白受体是细胞粘附受体整合素家族的成员。
Science. 1988 Sep 2;241(4870):1228-9. doi: 10.1126/science.2970671.
8
Molecular specificity of L2 monoclonal antibodies that bind to carbohydrate determinants of neural cell adhesion molecules and their resemblance to other monoclonal antibodies recognizing the myelin-associated glycoprotein.与神经细胞黏附分子碳水化合物决定簇结合的L2单克隆抗体的分子特异性及其与识别髓鞘相关糖蛋白的其他单克隆抗体的相似性。
Brain Res. 1986 Oct 22;385(2):237-44. doi: 10.1016/0006-8993(86)91069-3.
9
The novel carbohydrate epitope L3 is shared by some neural cell adhesion molecules.新型碳水化合物表位L3为一些神经细胞黏附分子所共有。
J Cell Biol. 1987 Jun;104(6):1597-602. doi: 10.1083/jcb.104.6.1597.
10
Families of neural adhesion molecules.神经黏附分子家族
Ciba Found Symp. 1989;145:156-69, discussion 169-72. doi: 10.1002/9780470513828.ch10.

引用本文的文献

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Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin.朊病毒家族蛋白、朊病毒和沙杜蛋白与钙连蛋白的膜结构域定位及相互作用
Membranes (Basel). 2021 Dec 13;11(12):978. doi: 10.3390/membranes11120978.
2
Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones.相互作用组分析确定了朊蛋白（PrP）及其哺乳动物旁系同源物与寡甘露糖型N-聚糖和内质网衍生伴侣蛋白之间的联系。
PLoS Pathog. 2009 Oct;5(10):e1000608. doi: 10.1371/journal.ppat.1000608. Epub 2009 Oct 2.
3
Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.
外周髓鞘蛋白22与α6β4整合素形成复合物，其缺失会改变施万细胞基膜。
J Neurosci. 2006 Jan 25;26(4):1179-89. doi: 10.1523/JNEUROSCI.2618-05.2006.
4
The HNK-1 Carbohydrate Epitope and the Human Eye in Health and Disease.HNK-1碳水化合物表位与健康和疾病状态下的人眼
Pathol Oncol Res. 1997;3(1):8-14. doi: 10.1007/BF02893345.
5
Paraproteinaemic neuropathies.副蛋白血症性神经病
Brain Pathol. 1999 Apr;9(2):361-8. doi: 10.1111/j.1750-3639.1999.tb00232.x.
6
The role of glycoproteins in neural development function, and disease.糖蛋白在神经发育、功能及疾病中的作用。
Mol Neurobiol. 1998 Apr;16(2):163-220. doi: 10.1007/BF02740643.
7
Identification of monoclonal antibody At5 as a new member of HNK-1 antibody family: the reactivity with myelin-associated glycoprotein and with two brain-specific proteoglycans, phosphacan and neurocan.单克隆抗体At5作为HNK-1抗体家族新成员的鉴定：与髓鞘相关糖蛋白以及两种脑特异性蛋白聚糖（phosphacan和neurocan）的反应性。
Neurochem Res. 1997 Feb;22(2):133-40. doi: 10.1023/a:1027355221525.
8
The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with L1 and neurite outgrowth.神经细胞黏附分子（NCAM）的第四个免疫球蛋白样结构域包含一个用于寡甘露糖型聚糖的碳水化合物识别结构域，该结构域与L1和神经突生长相关。
J Cell Biol. 1993 Jun;121(6):1409-21. doi: 10.1083/jcb.121.6.1409.
9
Determination of structural elements of the L2/HNK-1 carbohydrate epitope required for its function.对L2/HNK-1碳水化合物表位发挥其功能所需结构元件的测定。
Glycoconj J. 1994 Aug;11(4):345-52. doi: 10.1007/BF00731208.
10
Immunohistochemical localization of chondroitin sulfate proteoglycan and tenascin in the human eye compared with the HNK-1 epitope.与HNK-1表位相比，人眼中硫酸软骨素蛋白聚糖和腱生蛋白的免疫组织化学定位。
Graefes Arch Clin Exp Ophthalmol. 1994 Nov;232(11):657-65. doi: 10.1007/BF00171380.