年龄相关性黄斑变性与HMG Co-A还原酶抑制剂（他汀类药物）的保护作用：来自2005 - 2008年美国国家健康和营养检查调查的结果
Age-related macular degeneration and protective effect of HMG Co-A reductase inhibitors (statins): results from the National Health and Nutrition Examination Survey 2005-2008.
作者信息
Barbosa D T Q, Mendes T S, Cíntron-Colon H R, Wang S Y, Bhisitkul R B, Singh K, Lin S C
机构信息
Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Department of Ophthalmology, Stanford University, Stanford, CA, USA.
出版信息
Eye (Lond). 2014 Apr;28(4):472-80. doi: 10.1038/eye.2014.8. Epub 2014 Feb 7.
PURPOSE
To determine the association of hydroxymethylglutarylcoenzyme A (HMG Co-A) reductase inhibitor (statin) use with the prevalence of age-related macular degeneration (AMD).
METHODS
This cross-sectional study included 5604 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008, ≥ 40 years of age, who were ascertained with regard to the diagnosis of AMD, the use of statins, and comorbidities and health-related behaviors such as smoking.
RESULTS
The mean age of participants denying or confirming a history of AMD was 68 (SEM 0.90) and 55 (SEM 0.36) years, respectively. Individuals 68 years of age or older who were classified as long-term users of statins had statistically significant less self-reported AMD (odds ratio (OR) 0.64, 95% confidence interval (CI) 0.49-0.84; P=0.002), after adjusting for potential confounding variables. No significant association was found between the prevalence of AMD and statin consumption among subjects between 40 and 67 years of age (OR 1.61, 95% CI 0.85-3.03; P=0.137).
CONCLUSIONS
Our results suggest a possible beneficial effect of statin intake for the prevention of AMD in individuals 68 years of age or older.
目的
确定羟甲基戊二酰辅酶A（HMG Co-A）还原酶抑制剂（他汀类药物）的使用与年龄相关性黄斑变性（AMD）患病率之间的关联。
方法
这项横断面研究纳入了2005年至2008年美国国家健康与营养检查调查（NHANES）中年龄≥40岁的5604名参与者，这些参与者已确诊AMD、使用他汀类药物情况以及合并症和吸烟等与健康相关的行为。
结果
否认或确认有AMD病史的参与者的平均年龄分别为68岁（标准误0.90）和55岁（标准误0.36）。在调整潜在混杂变量后，68岁及以上被归类为长期使用他汀类药物的个体自我报告的AMD显著较少（优势比（OR）0.64，95%置信区间（CI）0.49 - 0.84；P = 0.002）。在40至67岁的受试者中，未发现AMD患病率与他汀类药物使用之间存在显著关联（OR 1.61，95% CI 0.85 - 3.03；P = 0.137）。
结论
我们的结果表明，他汀类药物摄入可能对预防68岁及以上个体的AMD具有有益作用。
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