Faggion C M, Atieh M, Zanicotti D G
1] Department of Periodontology, Faculty of Dentistry, University of Münster, Münster, Germany [2] Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Br Dent J. 2014 Feb;216(3):109-12. doi: 10.1038/sj.bdj.2014.47.
Industry-supported clinical trials may present better outcomes than those supported by other sources. The aim of this paper was to assess whether systematic reviews (SRs) published in periodontology and implant dentistry report and discuss the influence of funding sources on study results. Two reviewers conducted a comprehensive search in PubMed and the Cochrane Database of Systematic Reviews independently and in duplicate to identify SRs published up to 11 November 2012. Speciality dental journals and the reference lists of included SRs were also scrutinised. Information on the reporting and discussion of funding sources of primary studies included in the SRs was extracted independently and in duplicate. Any disagreement regarding SR selection or data extraction was discussed until consensus was achieved. Of 146 SRs included in the assessment, only 45 (31%) reported the funding sources of primary studies. Fourteen (10%) SRs discussed the potential influence of funding sources on study results, that is, sponsorship bias. Funding sources are inadequately reported and discussed in SRs in periodontology and implant dentistry. Assessment, reporting, and critical appraisal of potential sponsorship bias of meta-analytic estimates are paramount to provide proper guidance for clinical treatments.
行业资助的临床试验可能比其他来源资助的试验呈现出更好的结果。本文旨在评估牙周病学和种植牙科学领域发表的系统评价（SRs）是否报告并讨论了资金来源对研究结果的影响。两名评审员独立且重复地在PubMed和Cochrane系统评价数据库中进行全面检索，以识别截至2012年11月11日发表的SRs。牙科专业期刊以及纳入的SRs的参考文献列表也进行了审查。关于SRs中纳入的原始研究资金来源的报告和讨论信息由两人独立且重复地提取。在SR选择或数据提取方面的任何分歧都进行了讨论，直至达成共识。在评估纳入的146篇SRs中，只有45篇（31%）报告了原始研究的资金来源。14篇（10%）SRs讨论了资金来源对研究结果的潜在影响，即赞助偏倚。在牙周病学和种植牙科学的SRs中，资金来源的报告和讨论不足。对荟萃分析估计值潜在赞助偏倚的评估、报告和批判性评价对于为临床治疗提供适当指导至关重要。
