青少年癌症长期幸存者的心血管后遗症：一项队列关联研究。
Cardiovascular sequelae in long-term survivors of young peoples' cancer: a linked cohort study.
作者信息
van Laar M, Feltbower R G, Gale C P, Bowen D T, Oliver S E, Glaser A
机构信息
Division of Epidemiology and Biostatistics, University of Leeds, Room 8.49, Worlsey Building, Clarendon Way, Leeds LS2 9NL, UK.
1] Division of Epidemiology and Biostatistics, University of Leeds, Room 8.49, Worlsey Building, Clarendon Way, Leeds LS2 9NL, UK [2] Department of Cardiology, York Teaching Hospital NHS Foundation Trust, Wigginton Road, York YO31 8HE, UK.
出版信息
Br J Cancer. 2014 Mar 4;110(5):1338-41. doi: 10.1038/bjc.2014.37. Epub 2014 Feb 6.
BACKGROUND
We aimed to define the incidence and risk of cardiovascular late effects (LEs) identified from inpatient hospital episode statistics (HES) among long-term survivors of cancer in young people by age at diagnosis (0-14 and 15-29 years).
METHODS
Records from the Yorkshire Specialist Register of Cancer in Children and Young People (1991-2006) were linked to inpatient HES data (1996-2011) to assess rates of cardiovascular LEs. Rates were compared with the general population in Yorkshire using age-sex-matched HES records for the entire region.
RESULTS
Of 3247 survivors of cancer, 3.6% had at least one cardiovascular LE. Overall, cardiovascular hospitalisations for the childhood cohort were threefold higher compared with the general population, but did not differ for young adults. For young adults, increased rates were limited to pericardial disease, cardiomyopathy and heart failure, pulmonary heart disease, hypertension and conduction disorders.
CONCLUSIONS
Survivors of childhood and young adult cancer remain at increased risk of cardiovascular LEs compared with the general population.
背景
我们旨在通过诊断时的年龄（0 - 14岁和15 - 29岁）确定从住院患者医院事件统计数据（HES）中识别出的年轻癌症长期幸存者心血管迟发效应（LEs）的发生率和风险。
方法
将约克郡儿童和青少年癌症专科登记处（1991 - 2006年）的记录与住院患者HES数据（1996 - 2011年）相链接，以评估心血管迟发效应的发生率。使用整个地区年龄 - 性别匹配的HES记录，将发生率与约克郡的普通人群进行比较。
结果
在3247名癌症幸存者中，3.6%至少有一种心血管迟发效应。总体而言，儿童队列的心血管住院率比普通人群高三倍，但年轻成年人的情况没有差异。对于年轻成年人，增加的发生率仅限于心包疾病、心肌病和心力衰竭、肺心病、高血压和传导障碍。
结论
与普通人群相比，儿童期和年轻成年期癌症幸存者患心血管迟发效应的风险仍然较高。
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