布比卡因是一种有效的心脏钾通道阻滞剂。
Bupivacaine is an effective potassium channel blocker in heart.
作者信息
Courtney K R, Kendig J J
机构信息
Research Institute, Palo Alto Medical Foundation, CA 94301.
出版信息
Biochim Biophys Acta. 1988 Mar 22;939(1):163-6. doi: 10.1016/0005-2736(88)90058-2.
PMID:2450583
Abstract
The local anesthetic agent bupivacaine increases action potential duration in isolated frog atrial myocytes, and blocks two potassium conductances, IK and IK1. The effective concentrations, particularly for IK, are similar to those which depress the sodium conductance. Potassium channel block may thus contribute to bupivacaine's reported cardiotoxicity.
摘要
局部麻醉药布比卡因可增加离体青蛙心房肌细胞的动作电位持续时间，并阻断两种钾离子电导，即IK和IK1。有效浓度，尤其是对IK的有效浓度，与抑制钠离子电导的浓度相似。因此，钾通道阻滞可能是布比卡因所致心脏毒性的原因之一。
Zotero 插件