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本文引用的文献

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The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network.雌性胚胎干细胞中的两条活性 X 染色体通过调节 ESC 信号网络来阻止退出多能状态。
Cell Stem Cell. 2014 Feb 6;14(2):203-16. doi: 10.1016/j.stem.2013.11.022.
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Derivation of novel human ground state naive pluripotent stem cells.新型人类原始态未分化多能干细胞的衍生。
Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. Epub 2013 Oct 30.
3
X chromosome inactivation and epigenetic responses to cellular reprogramming.X 染色体失活与细胞重编程的表观遗传反应。
Annu Rev Genomics Hum Genet. 2013;14:85-110. doi: 10.1146/annurev-genom-091212-153530. Epub 2013 May 6.
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Epigenetic alterations in human pluripotent stem cells: a tale of two cultures.人类多能干细胞中的表观遗传改变：两种文化的故事。
Cell Stem Cell. 2012 Jul 6;11(1):9-15. doi: 10.1016/j.stem.2012.06.012.
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Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.人类多能干细胞及其分化衍生物中 DNA 甲基化的反复变化。
Cell Stem Cell. 2012 May 4;10(5):620-34. doi: 10.1016/j.stem.2012.02.013.
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Evolutionary diversity and developmental regulation of X-chromosome inactivation.X 染色体失活的进化多样性和发育调控。
Hum Genet. 2011 Aug;130(2):307-27. doi: 10.1007/s00439-011-1029-2. Epub 2011 Jun 18.
7
Regulation of X-chromosome inactivation by the X-inactivation centre.X 染色体失活中心对 X 染色体失活的调控。
Nat Rev Genet. 2011 Jun;12(6):429-42. doi: 10.1038/nrg2987.
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Molecular coupling of Xist regulation and pluripotency.Xist调控与多能性的分子偶联
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Blastocysts prepare for the race to be male.
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Detrimental effects of two active X chromosomes on early mouse development.
Development. 1990 May;109(1):189-201. doi: 10.1242/dev.109.1.189.

脱离基态：X 染色体失活打破分化障碍。

Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation.

机构信息

Department of Reproductive Medicine, University of California, San Diego, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA 92037, USA.

Department of Reproductive Medicine, University of California, San Diego, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA 92037, USA.

出版信息

Cell Stem Cell. 2014 Feb 6;14(2):131-2. doi: 10.1016/j.stem.2014.01.012.

DOI:10.1016/j.stem.2014.01.012
PMID:24506876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3984128/
Abstract

Female mouse embryonic stem cells (mESCs) contain two active X chromosomes, with one undergoing random inactivation upon differentiation. Schulz et al. (2014) now demonstrate that the presence of two active X chromosomes in mESCs prevents exit from pluripotency by blocking MAPK signaling, ensuring synchronization between X chromosome dosage compensation and development.

摘要

雌性小鼠胚胎干细胞（mESCs）含有两条活性 X 染色体，其中一条在分化过程中随机失活。Schulz 等人（2014 年）现在证明，mESCs 中两条活性 X 染色体的存在通过阻断 MAPK 信号通路阻止多能性的退出，确保 X 染色体剂量补偿和发育之间的同步。