Videla L A, Barros S B, Simizu K, Junqueira V B
Departamento de Ciencias Biológicas, Facultad de Medicina, Universidad de Chile, Santiago.
Cell Biochem Funct. 1988 Jan;6(1):47-52. doi: 10.1002/cbf.290060108.
The i.p. administration of 60 mg kg-1 body weight of lindane, the gamma-isomer of hexachlorocyclohexane, to fed rats led to an enhancement of hepatic lipid peroxidation after 24 h of treatment. This was evidenced by significant increases in the hepatic production and biliary release of thiobarbituric acid reactive substances, and in the biliary release of glutathione disulphide. Under these conditions, the content of cytochrome P450 was enhanced concomitantly with increases in the total microsomal oxygen uptake, superoxide radical generation and (+)-catechin (cyanid-3-ol) sensitive respiration. The glutathione status of hepatocytes was altered by lindane as the content and biliary release of glutathione disulphide was drastically augmented, leading to a decrease in the cellular and biliary GSH/GSSG ratios. It is suggested that lindane treatment leads to an induced oxidative capacity, which, in turn, alters the glutathione status of the liver tissue.
给喂食的大鼠腹腔注射60毫克/千克体重的林丹（六氯环己烷的γ-异构体），处理24小时后会导致肝脏脂质过氧化增强。这可通过硫代巴比妥酸反应性物质的肝脏生成和胆汁释放以及谷胱甘肽二硫化物的胆汁释放显著增加得到证明。在这些条件下，细胞色素P450的含量随着微粒体总氧摄取、超氧自由基生成和（+）-儿茶素（氰基-3-醇）敏感呼吸的增加而同时增加。林丹改变了肝细胞的谷胱甘肽状态，因为谷胱甘肽二硫化物的含量和胆汁释放急剧增加，导致细胞和胆汁中GSH/GSSG比值降低。有人认为，林丹处理会导致诱导的氧化能力，进而改变肝脏组织的谷胱甘肽状态。
