林丹引起的氧化应激。II. 肝脏谷胱甘肽状态变化的时间进程。

Lindane-induced oxidative stress. II. Time course of changes in hepatic glutathione status.

Barros S B, Videla L A, Simizu K, Van Halsema L, Junqueira V B

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brasil.

Xenobiotica. 1988 Nov;18(11):1305-10. doi: 10.3109/00498258809042254.

Abstract

Four hours after treatment of rats with lindane (60 mg/kg), hepatic GSH content was decreased (22%) and GSSG was increased (20%), while biliary concentration and excretion of both GSH and GSSG and bile flow were diminished. These changes coincide with the onset of hepatic lipid peroxidation. 2. The changes induced by lindane at 4 h disappeared at 6 h after treatment, but liver GSSG content (91%), biliary GSSG excretion (133%) and bile flow (42%) were enhanced at 24 h. 3. The data indicate that lindane treatment elicits marked changes in hepatocyte glutathione status, with a decrease in the GSH/GSSG ratio at early (2-4 h) and late (24 h) periods of poisoning.

摘要

用林丹（60毫克/千克）处理大鼠4小时后，肝脏谷胱甘肽（GSH）含量降低（22%），氧化型谷胱甘肽（GSSG）增加（20%），同时GSH和GSSG的胆汁浓度及排泄以及胆汁流量均减少。这些变化与肝脏脂质过氧化的开始相一致。2. 林丹在处理后4小时引起的变化在6小时消失，但在24小时时肝脏GSSG含量（91%）、胆汁GSSG排泄（133%）和胆汁流量（42%）增加。3. 数据表明，林丹处理引起肝细胞谷胱甘肽状态的显著变化，在中毒早期（2 - 4小时）和晚期（24小时）谷胱甘肽与氧化型谷胱甘肽的比例降低。