Lu Hong-hong, Guo Zhi-rong, Hu Xiao-shu, Wu Ming, Zhou Ming-hao, Zhou Zheng-yuan
Department of Endocrinology and Metabolism, Suzhou Municipal Hospital, Suzhou 215008, China. Email:
Zhonghua Yu Fang Yi Xue Za Zhi. 2013 Nov;47(11):1026-30.
The aim was to explore the association between high-sensitivity C-reactive protein level at baseline and hypertension in follow-up periods in a Chinese cohort.
We analyzed data from a cohort established in "Prevention of metabolic syndrome and multi-metabolic disorders in Jiangsu province" in April 2000. A follow-up investigation was carried out for those whose follow up time met 5 years in June 2006. A total of 2035 persons completed investigation and hs-CRP was tested. Subjects with normal baseline blood pressure were classified into four groups(514, 498, 515 and 508 subjects in each group) according to quartiles of hs-CRP level (<1.3, 1.3-1.9, 2.0-3.2 and ≥ 3.3 mg/L). The relationship between the risk of hypertension and baseline level of hs-CRP were analyzed using Cox proportional hazards regression model.
The median of follow up time was 6.39 years among the 2035 subjects (926 males and 1109 females). Hypertension incidence was 2378/100 000 person-years, 2942/100 000 person-years, 3693/100 000 person-years and 4390/100 000 person-years in hs-CRP < 1.3, 1.3-1.9, 2.0-3.2 and ≥ 3.3 mg/L groups respectively. Compared to the group of hs-CRP < 1.3 mg/L, the relative risk (RR) (95%CI) of hypertension in groups of hs-CRP 1.3-1.9, 2.0-3.2 and ≥ 3.3 mg/L was 1.22 (0.87-1.72), 1.43 (1.03-2.00), 1.70 (1.21-2.41) respectively, adjusted for sex, age, baseline blood pressure, BMI, smoking, alcohol drinking, physical activity and family history of myocardial infarction and diabetes.When stratified by quartiles of baseline blood pressure, the incidence of hypertension in each group increased with level of hs-CRP.In the group whose baseline SBP < 110 mm Hg (1 mm Hg = 0.133 kPa) , compared to the group of hs-CRP < 1.3 mg/L, RR (95%CI) were 2.24 (1.32-4.03), 2.57 (1.57-4.57) and 3.57 (2.54-5.90) in hs-CRP 1.3-1.9, 2.0-3.2 and ≥ 3.3 mg/L groups respectively.In the group whose baseline DBP < 65 mm Hg, RR (95%CI) were 1.78 (1.03-3.24), 2.74 (1.63-4.93) and 4.13 (2.35-7.27) respectively.
Inflammation was an important process in the development of hypertension.
探讨中国队列研究中基线高敏C反应蛋白水平与随访期高血压之间的关联。
我们分析了2000年4月在“江苏省代谢综合征及多种代谢紊乱的预防”中建立的队列数据。2006年6月对随访时间满5年的人群进行随访调查。共有2035人完成调查并检测了高敏C反应蛋白（hs-CRP）。基线血压正常的受试者根据hs-CRP水平四分位数（<1.3、1.3 - 1.9、2.0 - 3.2和≥3.3mg/L）分为四组（每组分别为514、498、515和508名受试者）。采用Cox比例风险回归模型分析高血压风险与hs-CRP基线水平之间的关系。
2035名受试者（926名男性和1109名女性）的随访时间中位数为6.39年。hs-CRP<1.3、1.3 - 1.9、2.0 - 3.2和≥3.3mg/L组的高血压发病率分别为2378/100 000人年、2942/100 000人年、- 3693/100 000人年和4390/100 000人年。与hs-CRP<1.3mg/L组相比，hs-CRP 1.3 - 1.9、2.0 - 3.2和≥3.3mg/L组高血压的相对风险（RR）（95%CI）分别为1.22（0.87 - 1.72）、1.43（1.03 - 2.00）、1.70（1.21 - 2.41），对性别、年龄、基线血压、体重指数、吸烟、饮酒、体力活动以及心肌梗死和糖尿病家族史进行了校正。按基线血压四分位数分层时，每组高血压发病率随hs-CRP水平升高而增加。在基线收缩压（SBP）<110mmHg（1mmHg = 0.133kPa）的组中，与hs-CRP<1.3mg/L组相比，hs-CRP 1.3 - 1.9、2.0 - 3.2和≥3.3mg/L组的RR（95%CI）分别为2.24（1.32 - 4.03）、2.57（1.57 - 4.57）和3.57（2.54 - 5.90）。在基线舒张压（DBP）<65mmHg的组中，RR（95%CI）分别为1.78（1.03 - 3.24）、2.74（1.63 - 4.93）和4.13（2.35 - 7.27）。
炎症是高血压发生发展的重要过程。
