Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), México, D.F. Mexico.
Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), México, D.F. Mexico.
Arch Med Res. 2014 Feb;45(2):103-15. doi: 10.1016/j.arcmed.2014.01.005. Epub 2014 Feb 4.
Calpain activity has been implicated in several cellular processes such as cell signaling, apoptosis, exocytosis, mitochondrial metabolism and cytoskeletal remodeling. Evidence has indicated that the impairment of calpain expression and the activity of different calpain family members are involved in diverse pathologies. Calpain-10 has been implicated in the development of type 2 diabetes, and polymorphisms in the CAPN10 gene have been associated with an increased risk of developing this disease. The present work focused on the molecular biology of calpain-10, supporting its key participation in glucose metabolism. Current knowledge regarding the role of calpain-10 in the development of type 2 diabetes mellitus and diabetes-related diseases is additionally reviewed.
钙蛋白酶活性与多种细胞过程有关，如细胞信号转导、细胞凋亡、胞吐作用、线粒体代谢和细胞骨架重塑。有证据表明，钙蛋白酶表达的损害和不同钙蛋白酶家族成员的活性参与了多种病理过程。钙蛋白酶-10 与 2 型糖尿病的发展有关，CAPN10 基因的多态性与患该病的风险增加有关。本工作重点研究钙蛋白酶-10 的分子生物学，支持其在葡萄糖代谢中的关键作用。此外，还回顾了钙蛋白酶-10 在 2 型糖尿病和糖尿病相关疾病发展中的作用的现有知识。
