Sultana Munia, Islam Md Mafizul, Hossain Md Murad, Rahman Md Anisur, Das Shuvo Chandra, Barman Dhirendra Nath, Mitu Farhana Siddiqi, Gupta Shipan Das
Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali 3814, Bangladesh.
Genomics Inform. 2023 Sep;21(3):e33. doi: 10.5808/gi.23023. Epub 2023 Sep 27.
Type 2 diabetes mellitus (T2DM) is a multifactorial, polygenic, and metabolically complicated disease. A large number of genes are responsible for the biogenesis of T2DM and calpain10 (CAPN10) is one of them. The association of numerous CAPN10 genetic polymorphisms in the development of T2DM has been widely studied in different populations and noticed inconclusive results. The present study is an attempt to evaluate the plausible association of CAPN10 polymorphism SNP-19 (rs3842570) with T2DM and T2DM-related anthropometric and metabolic traits in the Noakhali region of Bangladesh. This case-control study included 202 T2DM patients and 75 healthy individuals from different places in Noakhali. A significant association (p < 0.05) of SNP-19 with T2DM in co-dominant 2R/3R vs. 3R/3R (odds ratio [OR], 2.7; p=0.0014) and dominant (2R/3R) + (2R/2R) vs. 3R/3R (OR, 2.47; p=0.0011) genetic models was observed. High-risk allele 2R also showed a significant association with T2DM in the allelic model (OR, 1.67; p=0.0109). The genotypic frequency of SNP-19 variants showed consistency with Hardy-Weinberg equilibrium (p > 0.05). Additionally, SNP-19 genetic variants showed potential associations with the anthropometric and metabolic traits of T2DM patients in terms of body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, and triglycerides. Our approach identifies the 2R/3R genotype of SNP-19 as a significant risk factor for biogenesis of T2DM in the Noakhali population. Furthermore, a large-scale study could be instrumental to correlate this finding in overall Bangladeshi population.
2型糖尿病（T2DM）是一种多因素、多基因且代谢复杂的疾病。大量基因与T2DM的发生有关，钙蛋白酶10（CAPN10）就是其中之一。众多CAPN10基因多态性与T2DM发生之间的关联已在不同人群中广泛研究，但结果尚无定论。本研究旨在评估孟加拉国诺阿卡利地区CAPN10基因多态性SNP - 19（rs3842570）与T2DM以及T2DM相关人体测量和代谢特征之间可能存在的关联。这项病例对照研究纳入了来自诺阿卡利不同地点的202例T2DM患者和75名健康个体。在共显性2R/3R与3R/3R（优势比[OR]，2.7；p = 0.0014）以及显性（2R/3R）+（2R/2R）与3R/3R（OR，2.47；p = 0.0011）遗传模型中，观察到SNP - 19与T2DM存在显著关联（p < 0.05）。高危等位基因2R在等位基因模型中也显示与T2DM存在显著关联（OR，1.67；p = 0.0109）。SNP - 19变体的基因型频率符合哈迪 - 温伯格平衡（p > 0.05）。此外，SNP - 19基因变体在体重指数、收缩压、舒张压、总胆固醇和甘油三酯方面显示出与T2DM患者的人体测量和代谢特征存在潜在关联。我们的研究方法确定SNP - 19的2R/3R基因型是诺阿卡利人群中T2DM发生的一个重要风险因素。此外，大规模研究可能有助于将这一发现与整个孟加拉国人群相关联。
