Portillo-Reyes Verónica, Pérez-García Miguel, Loya-Méndez Yolanda, Puente Antonio E
Department of Psychology, Autonomous University of Ciudad Juarez, Mexico; Department of Clinical Psychology, University of Granada, Granada, Spain.
Department of Clinical Psychology, University of Granada, Granada, Spain; Research Center, Mind, Brain and Behavior (CIMCYC), University of Granada, Granada, Spain.
Res Dev Disabil. 2014 Apr;35(4):861-70. doi: 10.1016/j.ridd.2014.01.013. Epub 2014 Feb 6.
It has been shown that supplementation with omega-3 improves cognitive performance, especially in infants and toddlers, but it is unknown whether these results are effective in older malnourished children. The aims of this study, therefore, were to investigate the omega-3 supplementation effects in 8- to 12-year-old children and to know which neuropsychological functions improve after three months of intervention in a sample of Mexican children with mild to moderate malnutrition. This study was a randomized, double-blind, treatment and placebo study of 59 children aged 8-12 years who were individually allocated to 2 groups. The duration of the intervention lasted 3 months. Neuropsychological performance was measured at baseline and at 3 months. Results show that more than 50% of children in the treatment group had greater improvement in 11 of the 18 neuropsychological variables studied. Processing speed, visual-motor coordination, perceptual integration, attention and executive function showed improvement in more than 70% of the omega-3 supplemented children. This trial was registered at clinicaltrials.gov as NCT01199120.
研究表明，补充ω-3脂肪酸可改善认知能力，尤其是对婴幼儿，但尚不清楚这些结果对年龄较大的营养不良儿童是否有效。因此，本研究的目的是调查ω-3脂肪酸补充剂对8至12岁儿童的影响，并了解在对一组患有轻度至中度营养不良的墨西哥儿童进行三个月干预后，哪些神经心理功能得到了改善。本研究是一项针对59名8至12岁儿童的随机、双盲、治疗与安慰剂对照研究，这些儿童被随机分为两组。干预持续时间为3个月。在基线和3个月时测量神经心理表现。结果显示，治疗组中超过50%的儿童在18项研究的神经心理变量中的11项上有更大改善。在补充ω-3脂肪酸的儿童中，超过70%的儿童在处理速度、视动协调、知觉整合、注意力和执行功能方面有改善。该试验已在clinicaltrials.gov上注册，注册号为NCT01199120。
