Department of Neurobiology, Institute for Life Sciences and The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, 91904 Jerusalem, Israel.
Department of Neurobiology, Institute for Life Sciences and The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, 91904 Jerusalem, Israel.
Neuron. 2014 Mar 5;81(5):1097-1110. doi: 10.1016/j.neuron.2014.01.007. Epub 2014 Feb 6.
The adult mammalian brain is continuously supplied with adult-born neurons in the olfactory bulb (OB) and hippocampus, where they are thought to be important for circuit coding and plasticity. However, direct evidence for the actual involvement of these neurons in neural processing is still lacking. We recorded the spiking activity of adult-born periglomerular neurons in the mouse OB in vivo using two-photon-targeted patch recordings. We show that odor responsiveness reaches a peak during neuronal development and then recedes at maturity. Sensory enrichment during development enhances the selectivity of adult-born neurons after maturation, without affecting neighboring resident neurons. Thus, in the OB circuit, adult-born neurons functionally integrate into the circuit, where they acquire distinct response profiles in an experience-dependent manner. The constant flow of these sensitive neurons into the circuit provides it with a mechanism of long-term plasticity, wherein new neurons mature to process odor information based on past demands.
成年哺乳动物大脑在嗅球（OB）和海马体中不断产生成年神经元，这些神经元被认为对电路编码和可塑性很重要。然而，直接证明这些神经元实际参与神经处理的证据仍然缺乏。我们使用双光子靶向贴片记录在体内记录了成年小鼠嗅球内颗粒细胞层神经元的放电活动。我们发现，神经元发育过程中气味反应性达到峰值，然后在成熟时衰退。发育过程中的感官丰富会增强成年神经元的选择性，而不会影响邻近的常驻神经元。因此，在 OB 回路中，成年神经元以功能的方式整合到回路中，它们以经验依赖性的方式获得独特的反应模式。这些敏感神经元源源不断地流入回路，为其提供了一种长期可塑性的机制，其中新的神经元成熟后根据过去的需求处理气味信息。
