在线电容测量在聚羟基烷酸酯发酵优化中的应用。
Optimization of polyhydroxyalkanoates fermentations with on-line capacitance measurement.
机构信息
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
出版信息
Bioresour Technol. 2014 Mar;156:216-21. doi: 10.1016/j.biortech.2014.01.042. Epub 2014 Jan 22.
The aim of this work was to provide an effective methodology for optimization of the polyhydroxyalkanoates (PHAs) fermentation with Ralstonia eutropha by the on-line capacitance measurement. The present study found the capacitance values could reflect variations of microbial morphology and viability. Furthermore, oxygen uptake rate, specific oxygen uptake rate and specific growth rate were measured in real-time and compared with the capacitance value. In addition, a fed-batch control strategy based on the on-line capacitance measurement was proposed to improve the PHAs production by 22%.
本工作旨在提供一种有效的方法，通过在线电容测量来优化 Ralstonia eutropha 的聚羟基烷酸酯（PHA）发酵。本研究发现电容值可以反映微生物形态和活力的变化。此外，实时测量了耗氧速率、比耗氧速率和比生长速率，并与电容值进行了比较。此外，还提出了一种基于在线电容测量的补料分批控制策略，可将 PHA 的产量提高 22%。
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