用于基于干细胞的再生医学的工程化物理微环境。
Engineering physical microenvironment for stem cell based regenerative medicine.
作者信息
Han Yu Long, Wang Shuqi, Zhang Xiaohui, Li Yuhui, Huang Guoyou, Qi Hao, Pingguan-Murphy Belinda, Li Yinghui, Lu Tian Jian, Xu Feng
机构信息
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, 710049, China; Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Shaanxi, 710049, China.
Brigham Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Drug Discov Today. 2014 Jun;19(6):763-73. doi: 10.1016/j.drudis.2014.01.015. Epub 2014 Feb 7.
Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted.
在过去十年中，再生医学因其在改善人类健康方面的潜在应用而迅速发展。尽管面临重大挑战，但干细胞的定向分化有望再生多种组织和/或器官。最近的研究表明，物理微环境在调节干细胞命运和提高分化效率方面起着至关重要的作用。在这篇综述中，我们总结了对控制干细胞分化至关重要的主要物理线索。还强调了物理微环境构建技术的最新进展及其在控制干细胞命运方面的意义。
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