Zhang Ting, Gao Jie, Jin Zheng-Yu, Xu Xue-Ming, Chen Han-Qing
School of Biotechnology and Food Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, PR China.
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, PR China.
Int J Biol Macromol. 2014 Apr;65:436-40. doi: 10.1016/j.ijbiomac.2014.01.063. Epub 2014 Feb 6.
In this study, the protective effect of Lilium lancifolium polysaccharides (LLP) on streptozotocin (STZ)-induced diabetic mice and possible mechanism were investigated. The diabetic mice were administered with LLP for 28 days. The results showed that oral administration of LLP could significantly decrease blood glucose level and increase body weight loss in STZ-induced diabetic mice. LLP also significantly increased the activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) and decreased the level of malondialdehyde (MDA) in serum, liver, and kidney in STZ-induced diabetic mice. Moreover, histopathological examination showed that LLP could markedly improve the structure integrity of pancreatic islet tissue in STZ-induced diabetic mice. However, LLP had no significant effect on organ weight of liver and pancreas of diabetic mice, but significantly decreased kidney weight compared with diabetic control mice. This study suggested that LLP had hypoglycemic and antioxidant properties and could provide protective effect on STZ-induced diabetic mice.
本研究探讨了卷丹多糖（LLP）对链脲佐菌素（STZ）诱导的糖尿病小鼠的保护作用及其可能机制。给糖尿病小鼠连续28天灌胃LLP。结果表明，口服LLP可显著降低STZ诱导的糖尿病小鼠的血糖水平，并减轻体重下降。LLP还显著提高了STZ诱导的糖尿病小鼠血清、肝脏和肾脏中抗氧化酶超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）的活性，并降低了丙二醛（MDA）水平。此外，组织病理学检查显示，LLP可显著改善STZ诱导的糖尿病小鼠胰岛组织的结构完整性。然而，LLP对糖尿病小鼠肝脏和胰腺的器官重量无显著影响，但与糖尿病对照小鼠相比，显著降低了肾脏重量。本研究表明，LLP具有降血糖和抗氧化特性，对STZ诱导的糖尿病小鼠具有保护作用。
