College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China.
Food Funct. 2017 Jul 19;8(7):2523-2535. doi: 10.1039/c7fo00417f.
Mulberry fruit polysaccharide (MFP), one of the major active ingredients isolated from the mulberry fruit, possesses numerous bioactivities. In vitro hypoglycemic experiments showed that MFP had significant insulin-sensitizing activity through increasing insulin secretion and promoting pancreatic β cell proliferation. In vivo, the oral administration of MFP could significantly decrease blood glucose levels and increase body weight loss in streptozotocin (STZ)-induced diabetic mice. MFP also significantly decreased the level of malondialdehyde (MDA) and increased the activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in the liver in STZ-induced diabetic mice. And histopathological examination showed that MFP could markedly alleviate damage to pancreas, liver and kidney tissue in STZ-induced diabetic mice. This study suggested that MFP had antioxidant and hypoglycemic properties and could provide a protective effect on STZ-induced diabetic mice.
桑椹多糖（MFP）是从桑椹中分离得到的主要活性成分之一，具有多种生物活性。体外降血糖实验表明，MFP 通过增加胰岛素分泌和促进胰岛β细胞增殖，具有显著的胰岛素增敏活性。体内实验中，MFP 灌胃给药可显著降低链脲佐菌素（STZ）诱导的糖尿病小鼠的血糖水平，并增加其体重减轻。MFP 还可显著降低 STZ 诱导的糖尿病小鼠肝脏中丙二醛（MDA）的水平，并增加超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）等抗氧化酶的活性。组织病理学检查显示，MFP 可显著减轻 STZ 诱导的糖尿病小鼠胰腺、肝脏和肾脏组织的损伤。本研究表明，MFP 具有抗氧化和降血糖作用，可对 STZ 诱导的糖尿病小鼠提供保护作用。
