Salah Sabah, El-Wahab Zeinab H Abd, Farag Rabei S, Mostafa Mohsen M
Chemistry Department, Faculty of Science, Mansoura University, Egypt.
Chemistry Department, Faculty of Science, Al-Azhar University, Egypt.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 24;124:579-87. doi: 10.1016/j.saa.2014.01.082. Epub 2014 Jan 25.
The reactions of isatin Girard's T hydrazone, N,N,N-trimethyl-2-oxo-2[(2z)-2-(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazino]ethan ammonium chloride (IGT) and isatin Girard's P hydrazone, 1-{2-oxo-2-[(2z)(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazine]ethyl} pyridinium chloride (IGP), with Fe(3+), Al(3+), Sb(3+) and Sn(2+) salts afford different types of complexes. The isolated solid complexes were characterized by elemental analyses, molar conductance, spectral (IR, UV-Vis, (1)H NMR, mass), magnetic moment and thermal measurements. The results suggest that all the complexes are conducting in polar solvents (EtOH, H2O and DMF). The IR spectral data suggest that the ligands coordinate in a tridentate manner via the two carbonyl of both isatin and Girard's and the azomethine (C=N) groups. The amounts of solvents inside and outside the coordination sphere were determined using thermal data (TGA) and weight loss method. The octahedral geometry of the complexes is confirmed using DFT method from DMOL(3) calculations. The ligands and their metal complexes were tested against different strains of bacteria and fungi.
异吲哚酮吉拉德 T 腙（N,N,N - 三甲基 - 2 - 氧代 - 2[(2Z)-2-(2 - 氧代 - 1,2 - 二氢 - 3H - 吲哚 - 3 - 亚基)肼基]氯化铵，IGT）和异吲哚酮吉拉德 P 腙（1 - {2 - 氧代 - 2 - [(2Z)(2 - 氧代 - 1,2 - 二氢 - 3H - 吲哚 - 3 - 亚基)肼基]乙基}吡啶氯化铵，IGP）与铁（Ⅲ）、铝（Ⅲ）、锑（Ⅲ）和锡（Ⅱ）盐反应生成不同类型的配合物。通过元素分析、摩尔电导率、光谱（红外、紫外 - 可见、¹H NMR、质谱）、磁矩和热分析对分离得到的固体配合物进行了表征。结果表明，所有配合物在极性溶剂（乙醇、水和二甲基甲酰胺）中都具有导电性。红外光谱数据表明，配体通过异吲哚酮和吉拉德试剂的两个羰基以及偶氮甲碱（C=N）基团以三齿方式配位。利用热分析数据（热重分析）和失重法确定了配位球内外的溶剂量。通过 DMOL(3)计算的密度泛函理论方法证实了配合物的八面体几何结构。对配体及其金属配合物针对不同的细菌和真菌菌株进行了测试。
