Cui Wen-Yao, Liu Yan, Zhu Yong-Qiang, Song Tao, Wang Qiu-Shi
Department of Anaesthesiology, The First Hospital of China Medical University, Shenyang City, Liaoning Province, 110001, People's Republic of China,
Tumour Biol. 2014 Jun;35(6):5213-7. doi: 10.1007/s13277-014-1677-7. Epub 2014 Feb 9.
Propofol is one of the most commonly used intravenous anesthetic agents during cancer resection surgery. It can influence proliferation, motility, and invasiveness of cancer cells in vitro and in vivo. However, the role of the propofol in the lung cancer cells remains unclear. In this study, we demonstrated the effects of propofol on the proliferation and the apoptosis of lung cancer cell H460 by using colony formation assay and flow cytometry. Propofol also decreased tumor size and weight in established xenografted tumors. Furthermore, propofol-induced endoplasmic reticulum (ER) stress was determined by Western blot.
丙泊酚是癌症切除手术中最常用的静脉麻醉剂之一。它在体外和体内均可影响癌细胞的增殖、运动和侵袭能力。然而，丙泊酚在肺癌细胞中的作用仍不清楚。在本研究中，我们通过集落形成试验和流式细胞术证明了丙泊酚对肺癌细胞H460增殖和凋亡的影响。丙泊酚还可减小已建立的异种移植瘤的大小和重量。此外，通过蛋白质印迹法测定了丙泊酚诱导的内质网（ER）应激。
