在大鼠结扎去除后长期给予毛果芸香碱后，异丙肾上腺素和福斯高林对腮腺组织淀粉酶释放的影响。

Effect of isoproterenol and forskolin on amylase release from parotid tissue after chronic pilocarpine administration in rats following ligation removal.

作者信息

Murata K, Ogura Y

机构信息

Department of Pharmacology, School of Dentistry, Tohoku University, Sendai, Japan.

出版信息

Jpn J Pharmacol. 1987 Dec;45(4):545-9. doi: 10.1254/jjp.45.545.

DOI:10.1254/jjp.45.545

PMID:2451053

Abstract

The influence of chronic pilocarpine administration on the recovery of the parotid gland from an obstruction was investigated by studying the amylase release induced by secretagogues in rats. Treatment with pilocarpine (5 mg/kg, daily for 7 days) increased amylase release induced by isoproterenol (10(-5) M) or forskolin (10(-5) M) in the parotid tissue of rats after the removal of a 7-day-duct ligation. However, there was no significant difference in the amylase activity of the parotid tissue between pilocarpine-treated rats and control rats. These results suggest that the accelerated recovery of amylase release from parotid tissue in rats chronically treated with pilocarpine may be due to the increased response of amylase release, rather than the increased accumulation of secretory materials in the cells; and furthermore, cyclic AMP-mediated events may be involved in the increased response of amylase release.

摘要

通过研究大鼠中促分泌剂诱导的淀粉酶释放，探讨了长期给予毛果芸香碱对腮腺从梗阻中恢复的影响。在进行7天的导管结扎后，用毛果芸香碱（5mg/kg，每日一次，共7天）处理可增加大鼠腮腺组织中异丙肾上腺素（10⁻⁵M）或福斯高林（10⁻⁵M）诱导的淀粉酶释放。然而，毛果芸香碱处理的大鼠和对照大鼠腮腺组织的淀粉酶活性没有显著差异。这些结果表明，长期用毛果芸香碱处理的大鼠腮腺组织中淀粉酶释放的加速恢复可能是由于淀粉酶释放反应的增加，而不是细胞中分泌物质积累的增加；此外，环磷酸腺苷介导的事件可能参与了淀粉酶释放反应的增加。