Nanni Michela, Maroni Elisa, Bevini Maurizio, Cucchi Gianpaolo, Pignotti Elettra, Pilu Gianluigi, Rizzo Nicola, Ghi Tullio
Department of Obstetrics, S. Orsola-Malpighi General Hospital, University of Bologna, Italy.
Prenat Diagn. 2014 May;34(5):500-4. doi: 10.1002/pd.4339. Epub 2014 Mar 6.
The objective of this study is to investigate the reproducibility of 3D ultrasound to measure the fetal nasal bone (NB) at first trimester.
A group of singleton viable pregnancies attending the 11 to 13 + 6 weeks aneuploidy screening at the University of Bologna were prospectively selected. For each patient, fetal NB was measured by 2D ultrasound. Subsequently, a 3D ultrasound of the fetal head was acquired, and fetal NB was measured by offline analysis using the volume nuchal translucency software. The correlation between 2D and 3D ultrasounds and the reproducibility of fetal NB measurement at 3D ultrasound were assessed.
Overall, 161 Caucasian women were included in the study. At 3D ultrasound, NB measurement showed an excellent intraobserver [Oper 1, intraclass correlation coefficient (ICC) = 0.98; Oper 2, ICC = 0.921] and interobserver agreement (rc = 0.92). The agreement between 2D and 3D measurements was moderate (rc = 0.77).
A 3D ultrasound supported by the volume nuchal translucency software may provide reliable measurements of the fetal NB in the first trimester.
本研究旨在探讨孕早期三维超声测量胎儿鼻骨（NB）的可重复性。
前瞻性选取一组在博洛尼亚大学进行11至13⁺⁶周非整倍体筛查的单胎活胎妊娠孕妇。对每位患者，先用二维超声测量胎儿鼻骨。随后，获取胎儿头部的三维超声图像，并使用容积颈项透明带软件进行离线分析测量胎儿鼻骨。评估二维和三维超声之间的相关性以及三维超声测量胎儿鼻骨的可重复性。
总体而言，161名白人女性纳入本研究。在三维超声检查中，鼻骨测量显示观察者内一致性极佳[操作人员1，组内相关系数（ICC）=0.98；操作人员2，ICC=0.921]，观察者间一致性良好（rc=0.92）。二维和三维测量之间的一致性为中等（rc=0.77）。
容积颈项透明带软件辅助的三维超声可在孕早期提供可靠的胎儿鼻骨测量结果。
