Sutherland R M
Cancer Center for Experimental Therapeutics, University of Rochester School of Medicine and Dentistry, NY 14642.
Science. 1988 Apr 8;240(4849):177-84. doi: 10.1126/science.2451290.
Abnormal vascularization of malignant tumors is associated with the development of microregions of heterogeneous cells and environments. Experimental models such as multicell spheroids and a variety of new techniques are being used to determine the characteristics of these microregions and to study the interactions of the cells and microenvironments. The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research.
恶性肿瘤的异常血管生成与异质性细胞和环境的微区域形成有关。多细胞球体等实验模型以及各种新技术正被用于确定这些微区域的特征，并研究细胞与微环境之间的相互作用。肿瘤特殊的细胞微生态学影响着对治疗药物的反应性，并对癌症研究的未来方向具有启示意义。
