Acute toxicity of gliotoxin in hamsters.
作者信息
Frame R, Carlton W W
机构信息
Department of Veterinary Microbiology, Pathology and Public Health, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47905.
出版信息
Toxicol Lett. 1988 Mar;40(3):269-73. doi: 10.1016/0378-4274(88)90050-1.
PMID:2451322
Abstract
Acute toxicity studies of gliotoxin were done in hamsters given oral doses of 15, 25 and 35 mg/kg of gliotoxin. Surviving hamsters were killed at 72 h post-treatment. Most hamsters in the middle and high dose groups were dead or moribund within 24 h. Hamsters in these dose groups that survived for greater than 12 h had hepatic alterations of necrotizing and proliferative cholangitis with marked lymphoplasmacytic pericholangitis.
摘要
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