Richard J L, Dvorak T J, Ross P F
National Center for Agricultural Utilization Research, USDA, Agricultural Research Service, Peoria, IL 61604, USA.
Mycopathologia. 1996;134(3):167-70. doi: 10.1007/BF00436725.
Thirteen samples of infected turkey lung tissue from cases of 'airsacculitis' were collected either at the processing plant or from a local turkey farm and subjected to cultural and gliotoxin analysis. Aspergillus fumigatus was isolated from 6 of the 13 samples; all isolates were determined to be gliotoxin producers when grown in laboratory culture and assayed by HPLC procedures. Gliotoxin was isolated from 5 of the 13 tissue but was not isolated from all tissues that were infected with A. fumigatus. Gliotoxin was isolated from which no A. fumigatus was isolated and it was not detected in three tissues from which gliotoxin-producing isolates of A. fumigatus were obtained. The ability of this pathogenic fungs to produce this immunomodulating compound in naturally infected turkeys provides further evidence that gliotoxin may be involved in the pathogenesis of the disease, aspergillosis of turkeys.
从加工厂或当地火鸡养殖场采集了13份来自“气囊炎”病例的感染火鸡肺组织样本，并进行了培养和胶毒素分析。从13份样本中的6份分离出烟曲霉；当在实验室培养并通过HPLC程序检测时，所有分离株均被确定为胶毒素产生菌。从13份组织中的5份分离出了胶毒素，但并非所有感染烟曲霉的组织都能分离出胶毒素。在未分离出烟曲霉的组织中也分离出了胶毒素，而在获得产胶毒素烟曲霉分离株的3份组织中未检测到胶毒素。这种致病真菌在自然感染火鸡中产生这种免疫调节化合物的能力进一步证明，胶毒素可能参与了火鸡曲霉菌病的发病机制。
