Torinuki W, Mauduit G, Haftek M, Thivolet J
INSERM U.209, Hôpital Edouard-Herriot, Lyon, France.
Acta Derm Venereol. 1987;67(6):532-5.
Using OKT6 monoclonal antibody, we investigated the number of epidermal Langerhans' cells (LCs) in involved skin from patients with psoriasis, before and after mechlorethamine (HN2) or PUVA treatment. The number of LCs remained at about pretreatment number during three weeks of HN2 treatment alone, though they were reduced after 10 systemic PUVA treatments. Therefore, in contrast to PUVA which influences LCs, HN2 seems to have little effect on LCs. LCs in psoriatic plaques were, in number, 3-4 times less numerous than those in uninvolved, nontreated epidermis.
我们使用OKT6单克隆抗体，研究了银屑病患者受累皮肤在使用氮芥（HN2）或补骨脂素加紫外线A（PUVA）治疗前后表皮朗格汉斯细胞（LCs）的数量。单独使用HN2治疗三周期间，LCs数量维持在治疗前水平，不过在进行10次全身性PUVA治疗后，LCs数量减少。因此，与影响LCs的PUVA不同，HN2似乎对LCs影响很小。银屑病斑块中的LCs数量比未受累、未治疗表皮中的LCs数量少3至4倍。
