Richly Maximilian U, Türkcan Silvan, Le Gall Antoine, Fiszman Nicolas, Masson Jean-Baptiste, Westbrook Nathalie, Perronet Karen, Alexandrou Antigoni
Opt Express. 2013 Dec 16;21(25):31578-90. doi: 10.1364/OE.21.031578.
We present a new method for calibrating an optical-tweezer setup that does not depend on input parameters and is less affected by systematic errors like drift of the setup. It is based on an inference approach that uses Bayesian probability to infer the diffusion coefficient and the potential felt by a bead trapped in an optical or magnetic trap. It exploits a much larger amount of the information stored in the recorded bead trajectory than standard calibration approaches. We demonstrate that this method outperforms the equipartition method and the power-spectrum method in input information required (bead radius and trajectory length) and in output accuracy.
我们提出了一种用于校准光镊装置的新方法，该方法不依赖于输入参数，并且受装置漂移等系统误差的影响较小。它基于一种推理方法，该方法使用贝叶斯概率来推断捕获在光阱或磁阱中的珠子的扩散系数和感受到的势。与标准校准方法相比，它利用了记录的珠子轨迹中存储的大量信息。我们证明，在所需的输入信息（珠子半径和轨迹长度）和输出精度方面，该方法优于均分法和功率谱法。
