人C5a可诱导人嗜碱性粒细胞释放大量组胺，但对组织肥大细胞无此作用。

Human C5a induces a substantial histamine release in human basophils but not in tissue mast cells.

作者信息

Jürgensen H, Braam U, Pult P, Kownatzki E, Schmutzler W

机构信息

Abteilung Pharmakologie, Medizinische Fakultät der RWTH Aachen, BRD.

出版信息

Int Arch Allergy Appl Immunol. 1988;85(4):487-8. doi: 10.1159/000234557.

DOI:10.1159/000234557

PMID:2451646

Abstract

The histamine-releasing effect of human C5a was compared with that of concanavalin A in blood basophils and isolated adenoidal mast cells from the same donors. In basophils, C5a (10 ng/ml) induced a significant histamine release (7.5 +/- 2.1%, corrected value). In isolated adenoidal mast cells C5a had only a marginal effect (2% histamine release), although the cells responded markedly to concanavalin A stimulation (about 13% release). The results support the view that the heterogeneity of mast cells and basophils is also reflected in the expression of anaphylatoxin receptors on their surface.

摘要

将人C5a与伴刀豆球蛋白A对来自同一供体的血液嗜碱性粒细胞和分离的腺样体肥大细胞的组胺释放作用进行了比较。在嗜碱性粒细胞中，C5a（10 ng/ml）诱导了显著的组胺释放（校正值为7.5±2.1%）。在分离的腺样体肥大细胞中，C5a只有轻微作用（组胺释放2%），尽管这些细胞对伴刀豆球蛋白A刺激有明显反应（约13%释放）。结果支持这样一种观点，即肥大细胞和嗜碱性粒细胞的异质性也反映在其表面过敏毒素受体的表达上。