Roayaei Mahnaz, Ghasemi Sedighe
Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2013 Jul;18(7):580-2.
Androgen deprivation is the basis of treatment for advanced stages of prostate cancer. Cardiovascular disease may be a risk factor for mortality in prostate cancer. Therefore, we decided to evaluate the effect of androgen deprivation therapy (ADT) on the cardiovascular risk factors in patients with prostate cancer.
In a cross-sectional study on 2011, 35 patients suffering from metastatic prostate cancer as candidates for ADT were enrolled. Serum levels of fasting blood sugar (FBS), triglyceride (TG) and total cholesterol (TC) were measured at the beginning and after the 5(th) month of ADT.
The mean level of TG increased significantly from 130.82 ± 41.57 mg/dl to 150.05 ± 48.29 mg/dl (P < 0.012). Furthermore, serum level of TC increased from 197.62 ± 40.71 mg/dl to 212.54 ± 38.25 mg/dl, which is statistically significant (P < 0.001). A non-significant increase in the serum level of FBS from 96.74 ± 14.04 mg/dl to 99.17 ± 15.23 mg/dl was also seen (P = 0.27).
ADT in prostate cancer may lead to an increase in TG and TC levels. In patients with a high risk of cardiovascular disease patient's lipid profile should be considered during ADT.
雄激素剥夺是晚期前列腺癌治疗的基础。心血管疾病可能是前列腺癌患者死亡的一个危险因素。因此，我们决定评估雄激素剥夺疗法（ADT）对前列腺癌患者心血管危险因素的影响。
在一项2011年的横断面研究中，纳入了35例患有转移性前列腺癌且适合接受ADT的患者。在ADT开始时及第5个月后测量空腹血糖（FBS）、甘油三酯（TG）和总胆固醇（TC）的血清水平。
TG的平均水平从130.82±41.57mg/dl显著升高至150.05±48.29mg/dl（P<0.012）。此外，TC的血清水平从197.62±40.71mg/dl升高至212.54±38.25mg/dl，具有统计学意义（P<0.001）。FBS的血清水平也有非显著性升高，从96.74±14.04mg/dl升至99.17±15.23mg/dl（P=0.27）。
前列腺癌患者接受ADT可能会导致TG和TC水平升高。在心血管疾病高危患者接受ADT期间，应考虑其血脂情况。
