Mitani A, Ito K, Mitani Y, McCarley R W
Department of Psychiatry, Harvard Medical School, Brockton VAMC, Massachusetts 02401.
J Comp Neurol. 1988 Feb 22;268(4):546-66. doi: 10.1002/cne.902680406.
The trajectories and the cells of origin of the pontobulbar gigantocellular tegmental field descending pathways were studied in the cat using anterograde WGA-HRP and retrograde HRP techniques. Four main descending pathways and cells of origin were delineated: (1) Predominantly large neurons in the pontine gigantocellular tegmental field (average soma diameter = 43.4 microns) and rostral bulbar gigantocellular tegmental field (41.3 microns) gave rise to reticulospinal fibers descending in the ipsilateral medial longitudinal fasciculus and ventral funiculus and distributed in laminae V-X with an ipsilateral predominance. These were primarily large-diameter fibers. (2) Predominantly large neurons (46.9 microns) in the bulbar gigantocellular tegmental field gave rise to reticulospinal fibers descending in the contralateral medial longitudinal fasciculus and ventral funiculus. These were mainly large-diameter fibers. (3) Neurons of predominantly medium size (29.5 microns) in the pontine gigantocellular tegmental field gave rise to reticuloreticular fibers descending directly to and distributed bilaterally in the bulbar reticular formation. These were small-diameter fibers. (4) Neurons of predominantly medium size (28.9 microns) in the bulbar gigantocellular tegmental field gave rise to reticulospinal fibers descending in the ipsilateral reticular formation and lateral funiculus. These were small-diameter fibers.
运用顺行性WGA-HRP和逆行性HRP技术，在猫身上研究了脑桥延髓巨细胞被盖区下行通路的轨迹及起源细胞。确定了四条主要的下行通路及起源细胞：（1）脑桥巨细胞被盖区（平均胞体直径 = 43.4微米）和延髓嘴侧巨细胞被盖区（41.3微米）中主要为大型神经元，发出网状脊髓纤维，在同侧内侧纵束和腹侧索下行，并以同侧为主分布于V-X层。这些主要是大直径纤维。（2）延髓巨细胞被盖区中主要为大型神经元（46.9微米），发出网状脊髓纤维，在对侧内侧纵束和腹侧索下行。这些主要是大直径纤维。（3）脑桥巨细胞被盖区中主要为中等大小的神经元（29.5微米），发出网状网状纤维，直接下行至延髓网状结构并双侧分布。这些是小直径纤维。（4）延髓巨细胞被盖区中主要为中等大小的神经元（28.9微米），发出网状脊髓纤维，在同侧网状结构和外侧索下行。这些是小直径纤维。
