Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
J Physiol. 2011 Feb 1;589(Pt 3):653-65. doi: 10.1113/jphysiol.2010.201178. Epub 2010 Dec 13.
Voluntary limb movements are initiated in the brain but the neurones responsible for activating the muscles (motoneurones and interneurones) are located in the spinal cord. The spinal cord also contains neurones that provide the brain, and especially the cerebellum, with continuous information on effects of the descending commands. We show that one population of such neurones provide the cerebellum with information on how likely the brain's commands (mediated by descending reticulospinal neurones) are to be executed as planned, depending on the degree of inhibition of motoneurones. They may therefore play an important role in preventing errors in activation of motoneurones and thereby help the brain to correct its signals to the spinal cord before such errors have been committed.
自主肢体运动是由大脑发起的，但负责激活肌肉的神经元（运动神经元和中间神经元）位于脊髓中。脊髓中还包含神经元，这些神经元为大脑，特别是小脑，提供有关下行指令效果的持续信息。我们表明，这样的神经元群体之一为小脑提供了有关大脑指令（通过下行网状脊髓神经元介导）按计划执行的可能性的信息，这取决于运动神经元抑制的程度。因此，它们可能在防止运动神经元激活错误方面发挥重要作用，从而帮助大脑在发生此类错误之前纠正其向脊髓发送的信号。
