Awhin E P, Jeroh E, Anigboro A A, Rachael Nwaoroko
Department of Medical Biochemistry, College of Basic Medical Sciences, Delta State University, Abraka, Nigeria.
Department of Human Physiology, Faculty of Postgraduate Studies, Delta State University, Abraka, Nigeria.
Pak J Biol Sci. 2013 Dec 15;16(24):2062-5. doi: 10.3923/pjbs.2013.2062.2065.
The effect of chronic consumption of Piliostigma thonningii on the activities of Aspartate Aminotransferases (AST) and Alanine Aminotransferases (ALT) on serum and liver of Rattus novergicus was investigated in this research. The aim of this study was to check the possible effect of chronic consumption of Piliostigma thonningii on the activities of the liver biomarkers (ALT and AST) in Rattus novergicus. The results from this study revealed that the activities of aspartate aminotransferase (AST) in serum, showed a significant increase (34.20 +/- 12.9*) at (p < 0.05) upon chronic consumption of ethanolic extract of P. thonningii when compared with that of the control B (18.02 +/- 1.54). The result also showed that the liver AST was significantly increased (32.75 +/- 5.89*) when compared to that of the control B (17.01 +/- 1.81) at (p < 0.05). The results from the study also revealed that there was a significant increase in the activity of alanine aminotransferase in the liver (17.01 +/- 5.86*) when compared with that of the control B (5.1 +/- 1.11) at (p < 0.05). There was a corresponding increase in serum activity of the enzyme ALT (13.65 +/- 3.79*) when compared with that of the control B (9.4 +/- 1.98) at (p < 0.05). The results from this research has shown that chronic consumption of P. thonningii may cause liver injury thereby, increasing the liver enzyme activity (17.01 +/- 5.86*). This was shown in the corresponding increase in the serum level. Excessive consumption of the extract of P. thonningii has a toxicity potential on the liver and possibly other organs and tissues.
本研究调查了长期食用托宁氏猴面包树对褐家鼠血清和肝脏中天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）活性的影响。本研究的目的是检验长期食用托宁氏猴面包树对褐家鼠肝脏生物标志物（ALT和AST）活性的可能影响。本研究结果显示，与对照B组（18.02±1.54）相比，长期食用托宁氏猴面包树乙醇提取物后，血清中天冬氨酸转氨酶（AST）活性显著增加（34.20±12.9*），差异有统计学意义（p<0.05）。结果还显示，与对照B组（17.01±1.81）相比，肝脏AST活性显著增加（32.75±5.89*），差异有统计学意义（p<0.05）。研究结果还显示，与对照B组（5.1±1.11）相比，肝脏中丙氨酸转氨酶活性显著增加（17.01±5.86*），差异有统计学意义（p<0.05）。与对照B组（9.4±1.98）相比，该酶在血清中的活性相应增加（13.65±3.79*），差异有统计学意义（p<0.05）。本研究结果表明，长期食用托宁氏猴面包树可能会导致肝损伤，从而增加肝脏酶活性（17.01±5.86*）。血清水平的相应增加也证明了这一点。过量食用托宁氏猴面包树提取物对肝脏以及可能对其他器官和组织具有潜在毒性。
