Sgouros D, Lallas A, Julian Y, Rigopoulos D, Zalaudek I, Longo C, Moscarella E, Simonetti V, Argenziano G
Second Department of Dermatology, Athens University School of Medicine, Attikon General University Hospital, Chaidari, Athens, Greece.
Skin Res Technol. 2014 Nov;20(4):440-4. doi: 10.1111/srt.12138. Epub 2014 Feb 11.
BACKGROUND/PURPOSE: Spectrophotometric Intracutaneous Analysis (SIAscopy) is a non-invasive, computerized technique for the diagnosis of pigmented skin tumours. The analysis is based on the evaluation of skin chromophores, i.e. melanin, haemoglobin and collagen within the epidermis and papillary dermis. Our aim was to assess the diagnostic validity of SIAscopy in the detection of melanoma and non-melanoma skin cancers compared to the clinical-dermoscopic diagnosis and the histopathologic results of the excised lesions.
In total, 188 lesions of 180 patients were examined by dermoscopy and SIAscopy. A SIAscopy scoring system was first compared with the clinical-dermoscopic diagnosis and then with the histopathologic diagnosis of the excised lesions.
With respect to the clinical-dermoscopic evaluation, SIAscopy had sensitivity and specificity values of 85.7% and 65.4% respectively. Of the 188 evaluated lesions, 44 were excised with histopathologic examination revealing 31 malignant tumours, including 18 melanomas. With respect to histopathology SIAscopy had a sensitivity of 83.9%. Seven of the 13 benign excised lesions were scored as malignant by SIAscopy resulting in a specificity of 46.1%.
SIAscopy cannot replace the standard of care in skin cancer diagnosis, which includes clinical and dermoscopic examination. However, considering that the technique does not require specific training and expertise, it might represent an additional, relatively cost-effective tool to select lesions for referral.
背景/目的：分光光度法皮内分析（SIAscopy）是一种用于诊断色素性皮肤肿瘤的非侵入性计算机技术。该分析基于对皮肤发色团的评估，即表皮和乳头真皮内的黑色素、血红蛋白和胶原蛋白。我们的目的是评估SIAscopy在检测黑色素瘤和非黑色素瘤皮肤癌方面与临床皮肤镜诊断以及切除病变的组织病理学结果相比的诊断有效性。
总共对180例患者的188个病变进行了皮肤镜检查和SIAscopy检查。首先将SIAscopy评分系统与临床皮肤镜诊断进行比较，然后与切除病变的组织病理学诊断进行比较。
关于临床皮肤镜评估而言，SIAscopy的敏感性和特异性值分别为85.7%和65.4%。在188个评估病变中，44个进行了切除并经组织病理学检查，结果显示有31个恶性肿瘤，包括18个黑色素瘤。关于组织病理学，SIAscopy的敏感性为83.9%。13个切除的良性病变中有7个被SIAscopy评为恶性，特异性为46.1%。
SIAscopy不能替代皮肤癌诊断的标准护理方法，后者包括临床和皮肤镜检查。然而，考虑到该技术不需要特定的培训和专业知识，它可能是一种额外的、相对具有成本效益的工具，用于选择需要转诊的病变。
