Balagula Yevgeniy, Kang Sewon, Patel Manisha J
Department of Dermatology, Johns Hopkins Medicine, Baltimore, MD, USA.
Photodermatol Photoimmunol Photomed. 2015 Jan;31(1):15-25. doi: 10.1111/phpp.12115. Epub 2014 Mar 6.
Nonmelanoma skin cancers (NMSCs) are the most common malignancies in the United States in immunocompetent patients. Among the solid-organ transplant recipients, NMSCs represent a significant disease burden, and they tend to be multiple and more aggressive. While the precise mechanisms responsible for the higher risk of developing cutaneous squamous cell carcinomas (SCCs) have not been completely elucidated, ultraviolet (UV) light has been established to be critical in initiation and promotion of tumor development. More recently, significant emphasis has been placed on the role of the mammalian target of rapamycin (mTOR) pathway in SCC pathogenesis. Furthermore, some studies have demonstrated the ability of mTOR inhibitors to decrease the incidence of new SCCs in the immunosuppressed transplanted patient population. In this review, we will highlight and examine the most recent available data on the role of UV radiation and its interaction with mTOR pathway signaling in SCC pathogenesis.
非黑色素瘤皮肤癌（NMSCs）是免疫功能正常的美国患者中最常见的恶性肿瘤。在实体器官移植受者中，NMSCs是一个重大的疾病负担，且往往为多发性且侵袭性更强。虽然导致皮肤鳞状细胞癌（SCCs）发生风险较高的确切机制尚未完全阐明，但紫外线（UV）已被确认为在肿瘤发生的起始和促进过程中起关键作用。最近，人们高度重视雷帕霉素靶蛋白（mTOR）通路在SCC发病机制中的作用。此外，一些研究已证明mTOR抑制剂能够降低免疫抑制的移植患者群体中新发SCC的发生率。在本综述中，我们将着重介绍并审视关于紫外线辐射在SCC发病机制中的作用及其与mTOR通路信号传导相互作用的最新可用数据。
