Fukayama M, Maeda Y, Funata N, Koike M, Saito K, Sakai T, Ikeda T
Department of Pathology, Tokyo Metropolitan Komagome Hospital, Japan.
Am J Clin Pathol. 1988 May;89(5):617-21. doi: 10.1093/ajcp/89.5.617.
Two cases of the thymoma of the unusual sites were examined immunohistochemically. The one was intrapulmonary, and the other was diffuse pleural tumors. The infiltrating lymphocytes were T-cells showing OKT 6 positivity and nuclear immunoreactivity for terminal deoxynucleotidyl transferase (TdT) in the intrapulmonary tumor, like lymphocytes in the mediastinal thymoma of predominantly lymphocytic or mixed types. Although lymphocytes were dispersed in the pleural tumor, there were some TdT(+) OKT 6(-) lymphocytes and the similar finding was observed in the thymoma of predominantly epithelial type. In lung carcinomas and pleural mesotheliomas, there were no TdT(+) OKT 6(+/-) lymphocytes. Immunohistochemical studies using lymphocyte markers may be an useful tool for the diagnosis of the thymoma of ectopic site or unusual presentation.
对两例罕见部位胸腺瘤进行了免疫组织化学检查。一例为肺内胸腺瘤，另一例为弥漫性胸膜肿瘤。肺内肿瘤中的浸润淋巴细胞为T细胞，呈OKT 6阳性，对末端脱氧核苷酸转移酶（TdT）呈核免疫反应阳性，类似于主要为淋巴细胞型或混合型的纵隔胸腺瘤中的淋巴细胞。虽然淋巴细胞分散在胸膜肿瘤中，但存在一些TdT(+)OKT 6(-)淋巴细胞，且在主要为上皮型的胸腺瘤中也观察到类似发现。在肺癌和胸膜间皮瘤中，不存在TdT(+)OKT 6(+/-)淋巴细胞。使用淋巴细胞标志物的免疫组织化学研究可能是诊断异位部位或不典型表现胸腺瘤的有用工具。
