Zheng Shu
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2014 Jan;17(1):1-5.
Ninety percent of malignant tumor treatment failure is due to post-operative metastasis and recurrence. Paget's "seed and soil" in 1889 and Ewing's "tumor metastatic fluid dynamics" in 1928 are the basic scientific concepts of metastasis. With the advanced molecular biological technology combined with the translational medicine research, possible or potential metastatic "seed"-tumor stem cells or stemness cells can be screened. In recent years, study on the "tumor derived exosome" raised the concept of pre-metastatic niche and progenitor metastasis. On the other hand, associated methodology and technology for screening and detection of the exosome had been established, which provides feasible methods for screening, prediction and individual therapy. It will be the new era for cancer prevention and intervention in translational medicine area.
90%的恶性肿瘤治疗失败是由于术后转移和复发。1889年佩吉特提出的“种子与土壤”学说以及1928年尤因提出的“肿瘤转移流体动力学”是转移的基础科学概念。随着先进分子生物技术与转化医学研究相结合，可以筛选出可能的或潜在的转移性“种子”——肿瘤干细胞或具有干性的细胞。近年来，对“肿瘤来源外泌体”的研究提出了前哨转移微环境和始祖细胞转移的概念。另一方面，已建立了外泌体筛选和检测的相关方法和技术，为筛选、预测和个体化治疗提供了可行的方法。这将是转化医学领域癌症预防和干预的新时代。
