de Groot Amber E, Roy Sounak, Brown Joel S, Pienta Kenneth J, Amend Sarah R
The James Buchanan Brady Urological Institute at the Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Biological Sciences and UIC Cancer Center, University of Illinois at Chicago, Chicago, Illinois.
Mol Cancer Res. 2017 Apr;15(4):361-370. doi: 10.1158/1541-7786.MCR-16-0436. Epub 2017 Feb 16.
Metastasis is the consequence of a cancer cell that disperses from the primary tumor, travels throughout the body, and invades and colonizes a distant site. On the basis of Paget's 1889 hypothesis, the majority of modern metastasis research focuses on the properties of the metastatic "seed and soil," but the implications of the primary tumor "soil" have been largely neglected. The rare lethal metastatic "seed" arises as a result of the selective pressures in the primary tumor. Optimal foraging theory describes how cancer cells adopt a mobile foraging strategy to balance predation risk and resource reward. Further selection in the dispersal corridors leading out of the primary tumor enhances the adaptive profile of the potentially metastatic cell. This review focuses on the selective pressures of the primary tumor "soil" that generate lethal metastatic "seeds" which is essential to understanding this critical component of prostate cancer metastasis. Elucidating the selective pressures of the primary tumor "soil" that generate lethal metastatic "seeds" is essential to understand how and why metastasis occurs in prostate cancer. .
转移是癌细胞从原发肿瘤扩散、遍布全身并侵袭和定植于远处部位的结果。基于佩吉特1889年提出的假说，大多数现代转移研究聚焦于转移性“种子与土壤”的特性，但原发肿瘤“土壤”的影响在很大程度上被忽视了。罕见的致死性转移性“种子”是原发肿瘤中选择性压力的结果。最优觅食理论描述了癌细胞如何采用移动觅食策略来平衡捕食风险和资源回报。在离开原发肿瘤的扩散通道中的进一步选择增强了潜在转移性细胞的适应性特征。本综述聚焦于原发肿瘤“土壤”产生致死性转移性“种子”的选择性压力，这对于理解前列腺癌转移这一关键组成部分至关重要。阐明原发肿瘤“土壤”产生致死性转移性“种子”的选择性压力对于理解前列腺癌转移的发生方式和原因至关重要。
