Movement Disorders Unit, Department of Neurology, Westmead Hospital, Sydney, New South Wales, Australia.
Mov Disord. 2014 May;29(6):835-8. doi: 10.1002/mds.25739. Epub 2013 Nov 20.
Proximal-dominant upper limb tremor is highly disabling, and there is no effective medical therapy. In this study, we evaluated the efficacy of botulinum toxin (BTX) injections for the treatment of proximal tremor.
We conducted a retrospective analysis of open-label treatment with BTX in 19 patients with proximal tremor. The response to therapy was graded into four categories according to self-reported improvements in tremor and function.
In total, 63% of patients reported moderate or marked benefit, defined as functional improvements sufficient enough to allow feeding or drinking from a cup; whereas 21% of patients reported mild benefit; and 15% of patients reported no benefit. One patient developed severe weakness of shoulder abduction and withdrew from the treatment; otherwise, the therapy was free of side effects.
The current findings support the efficacy of BTX therapy in the treatment of proximal upper limb tremor with minimal side effects.
上肢近端优势性震颤严重致残，目前尚无有效的医学治疗方法。本研究评估了肉毒毒素（BTX）注射治疗近端震颤的疗效。
我们对 19 例近端震颤患者进行了 BTX 开放性标签治疗的回顾性分析。根据震颤和功能改善的自我报告，将治疗反应分为四级。
共有 63%的患者报告有中度或明显的益处，定义为功能改善足以允许从杯子中进食或饮水；21%的患者报告有轻度益处；15%的患者报告无益处。1 例患者出现严重的肩部外展无力并退出治疗；否则，该治疗无副作用。
目前的研究结果支持 BTX 治疗在治疗近端上肢震颤方面的有效性，且副作用最小。
